{"id":"W3000454675","doi":"10.3389/fimmu.2019.02926","title":"Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Kenneth Rainin Foundation; McGill University","keywords":"Steatosis; Nonalcoholic fatty liver disease; Fatty liver; Internal medicine; Steatohepatitis; Inflammasome; Knockout mouse; Endocrinology; Gut flora; Pyroptosis; Caspase; Lipid metabolism; Insulin resistance; Metabolic syndrome; Dysbiosis; Biology; Inflammation; Obesity; Medicine; Apoptosis; Immunology; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004127297,0.0008265832,0.0006088542,0.0009379624,0.0002986999,0.0005907101,0.0003823858,0.0008907078,0.001917182],"category_scores_gemma":[0.0002285219,0.0005006323,0.0007185668,0.0004428059,0.0008175077,0.0006343191,0.0003795014,0.002458192,0.0005928082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004545609,"about_ca_system_score_gemma":0.0003984075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000649088,"about_ca_topic_score_gemma":0.0008894836,"domain_scores_codex":[0.9995062,0.00006826017,0.00008152162,0.0001427339,0.00009072763,0.00011058],"domain_scores_gemma":[0.9994634,0.00002890356,0.000223585,0.0000521508,0.00003979641,0.0001921001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00195835,0.0003346318,0.0007679228,0.0001029546,0.00002628824,0.0001118007,0.00006089764,0.0001416031,0.9948368,0.0001893649,0.00008423541,0.001385123],"study_design_scores_gemma":[0.0006240183,0.004472369,0.02981843,0.00008962032,0.0001841752,0.001136421,0.000378547,0.003656575,0.9538261,0.0005625564,0.005191201,0.00005990492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906855,0.001670822,0.00388168,0.0004544077,0.0001019853,0.00008442596,0.001823711,0.0002159362,0.001081419],"genre_scores_gemma":[0.9831569,0.002081979,0.00640142,0.0004762832,0.00003545347,0.0002944525,0.001974886,0.0001273851,0.005451319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917182,"threshold_uncertainty_score":0.006413639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072273523599541,"score_gpt":0.2216841209725176,"score_spread":0.2109613857365222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}