{"id":"W3000472092","doi":"10.29173/hsi238","title":"It’s In Your Genes: Recent Considerations in Germline versus Somatic Gene Therapy","year":2017,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Germline; Somatic cell; Gene; Genetics; Biology; Genetic enhancement; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006764379,0.0001015033,0.0001293292,0.0001067432,0.0002920814,0.0000718446,0.0002704572,0.00005603731,0.0000160621],"category_scores_gemma":[0.0001967367,0.00009970339,0.00002117465,0.0001134403,0.0002713974,0.00001249752,0.00009328342,0.00008210089,0.000004579347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005745912,"about_ca_system_score_gemma":0.0006311181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009219944,"about_ca_topic_score_gemma":0.0006862893,"domain_scores_codex":[0.998823,0.00001860347,0.0002853046,0.0003316123,0.0001594099,0.0003819998],"domain_scores_gemma":[0.9991859,0.00001082247,0.00008781249,0.0005472409,0.0000514861,0.0001167248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001530189,0.0003502366,0.05277323,0.00008847329,0.00001439686,0.00003324676,0.004976085,0.008016512,0.8606333,0.0003082471,0.001878963,0.07077433],"study_design_scores_gemma":[0.006000176,0.0008855959,0.6514108,0.0001169906,0.000003290488,0.00005229175,0.001639056,0.004449361,0.3096629,0.0003157718,0.02474569,0.0007181293],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989954,0.002348513,0.0006445597,0.005601338,0.0009988081,0.0002543804,0.000002497325,0.000006946549,0.0001889526],"genre_scores_gemma":[0.9932027,0.003793826,0.001975083,0.0007976529,0.0001697573,0.00002740969,0.000006882514,0.000008422172,0.00001825227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5986375,"threshold_uncertainty_score":0.4065786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.154462188590905,"score_gpt":0.4702841788560662,"score_spread":0.3158219902651611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}