{"id":"W3000472092","doi":"10.29173/hsi238","title":"It’s In Your Genes: Recent Considerations in Germline versus Somatic Gene Therapy","year":2017,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Germline; Somatic cell; Gene; Genetics; Biology; Genetic enhancement; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02461277,0.0005346837,0.001414134,0.001154101,0.002516998,0.006939266,0.002305916,0.01136963,0.004041629],"category_scores_gemma":[0.01910526,0.0003635388,0.0008888041,0.0009990761,0.0213782,0.009984541,0.002719231,0.01685854,0.0006828028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004568085,"about_ca_system_score_gemma":0.006096201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002409339,"about_ca_topic_score_gemma":0.005829649,"domain_scores_codex":[0.9958526,0.001714313,0.0003868179,0.0005604403,0.001172097,0.0003138276],"domain_scores_gemma":[0.9754497,0.01996221,0.0008342984,0.0005844336,0.002143375,0.001025958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003480671,0.0001716411,0.000620261,0.001294523,0.00005064883,0.0007904041,0.001008776,0.0008126248,0.002735803,0.7046745,0.05852392,0.2289688],"study_design_scores_gemma":[0.0001261104,0.0005120959,0.0006666874,0.001890928,0.0001056573,0.001938989,0.001657551,0.00097248,0.002662383,0.4119888,0.5773767,0.0001015718],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.003335343,0.311498,0.01476541,0.6423624,0.01191675,0.00003144391,0.00004644592,0.00007700456,0.01596715],"genre_scores_gemma":[0.1627742,0.3780966,0.01820427,0.383864,0.04596411,0.0002398997,0.00007796368,0.0001849875,0.01059384],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02461277,"threshold_uncertainty_score":0.1301664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.154462188590905,"score_gpt":0.4702841788560662,"score_spread":0.3158219902651611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}