{"id":"W3000496134","doi":"10.1021/acs.biochem.9b00888","title":"Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding","year":2020,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval; PROTEO; Institut National de la Recherche Scientifique","funders":"Office of Advanced Cyberinfrastructure; Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"RNase P; Ribonuclease; RNase PH; Pancreatic ribonuclease; Ligand (biochemistry); Active site; Hydrolase; RNase MRP; RNase H; Enzyme; Binding site; Chemistry; Nucleotide; Biology; Biochemistry; Stereochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007850801,0.0001494232,0.000160873,0.00008443694,0.000179189,0.0002189388,0.0001510815,0.0002128056,0.00116551],"category_scores_gemma":[0.0001600688,0.00011107,0.0001563737,0.00009438824,0.0001982201,0.0002117575,0.00008391686,0.0003334698,0.0002145084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251672,"about_ca_system_score_gemma":0.0001548068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175809,"about_ca_topic_score_gemma":0.001263493,"domain_scores_codex":[0.9999579,0.000005221302,0.000001321114,0.00001023944,0.00001647078,0.000008913265],"domain_scores_gemma":[0.9999392,0.00001801564,0.00001634483,0.000004215633,0.000008042788,0.00001424597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002816988,0.00008558902,0.005147703,0.00008590148,0.00002856562,0.0003572649,0.0002226974,0.005935129,0.9821211,0.000722445,0.0003121501,0.004699918],"study_design_scores_gemma":[0.0001195576,0.001238459,0.1194909,0.00002628681,0.00007533678,0.002053966,0.0008305556,0.1386151,0.7268557,0.002093869,0.008439408,0.0001608994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972689,0.0003550228,0.001306648,0.00004779411,0.000004788729,0.000003454199,0.00009335971,0.00003907607,0.0008810242],"genre_scores_gemma":[0.9980659,0.0002659623,0.0009586969,0.00002791338,0.000004065416,0.000003984526,0.0002566817,0.00001103719,0.0004058337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175809,"threshold_uncertainty_score":0.003899038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00991575497606624,"score_gpt":0.2446235298823025,"score_spread":0.2347077749062363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}