{"id":"W3000504058","doi":"10.1093/carcin/bgaa001","title":"Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"National Cancer Institute; National Institute on Aging; National Institutes of Health; China Scholarship Council; Deutsche Forschungsgemeinschaft","keywords":"Cancer research; In vivo; Sildenafil; Medicine; Cancer cell; Pharmacology; Cancer; Repurposing; Drug repositioning; Apoptosis; Hsp90 inhibitor; cGMP-specific phosphodiesterase type 5; Hsp90; Internal medicine; Biology; Heat shock protein; Drug; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006748295,0.0002842005,0.0002187066,0.0001382969,0.0001286566,0.0002555769,0.0001090009,0.0001913193,0.001184902],"category_scores_gemma":[0.00006451876,0.0001038236,0.0002410985,0.0001095316,0.0001254351,0.0001351627,0.0001210622,0.000478073,0.0002143698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710051,"about_ca_system_score_gemma":0.0001328105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002993985,"about_ca_topic_score_gemma":0.0006439356,"domain_scores_codex":[0.9999017,0.0000157086,0.000008803879,0.00001954965,0.00002276153,0.00003145736],"domain_scores_gemma":[0.9999645,0.000006233633,0.00001196493,0.000006294987,0.000002494796,0.000008515866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446146,0.00004383613,0.0002204106,0.00002997574,0.000007883474,0.00008878022,0.000008617944,0.00005420984,0.9978823,0.00007787182,0.00009357086,0.00134794],"study_design_scores_gemma":[0.00001629409,0.0005364235,0.008535726,0.000004080354,0.00001923766,0.0002986566,0.00002394165,0.0009001031,0.9878556,0.00004772412,0.00175838,0.000003872375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919568,0.003429412,0.00218223,0.0001616255,0.0001101368,0.00002414677,0.0004773242,0.0001263042,0.001532101],"genre_scores_gemma":[0.996444,0.001238598,0.0005192634,0.00007536437,0.00001653928,0.00001579508,0.0003974862,0.000007253546,0.001285668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184902,"threshold_uncertainty_score":0.003963947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02767838461893081,"score_gpt":0.2455185666921866,"score_spread":0.2178401820732558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}