{"id":"W3000504058","doi":"10.1093/carcin/bgaa001","title":"Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"National Cancer Institute; National Institute on Aging; National Institutes of Health; China Scholarship Council; Deutsche Forschungsgemeinschaft","keywords":"Cancer research; In vivo; Sildenafil; Medicine; Cancer cell; Pharmacology; Cancer; Repurposing; Drug repositioning; Apoptosis; Hsp90 inhibitor; cGMP-specific phosphodiesterase type 5; Hsp90; Internal medicine; Biology; Heat shock protein; Drug; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006176151,0.00008745645,0.0001489418,0.00001450428,0.00003105382,0.000003687541,0.00005525419,0.00006320183,0.0000159205],"category_scores_gemma":[0.00006116812,0.00007633023,0.00006340782,0.00007238516,0.00007231075,0.000006253496,0.00004581087,0.00002243514,5.367713e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004595958,"about_ca_system_score_gemma":0.00002993304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002576655,"about_ca_topic_score_gemma":0.000002432836,"domain_scores_codex":[0.9993579,0.0000576438,0.00020676,0.0002034799,0.00009814048,0.00007601909],"domain_scores_gemma":[0.9995744,0.00001052073,0.0001342084,0.0001501115,0.00008006883,0.00005074282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816416,0.0000184653,0.01457874,0.00007901972,0.00001423588,3.043113e-7,0.0001282466,0.00004019793,0.9836946,0.00001910067,0.000472354,0.0007731211],"study_design_scores_gemma":[0.0004480267,0.0001329944,0.02842233,0.00001415301,0.00002378307,0.000002477859,0.0001181455,0.00006244776,0.9695632,0.00001885945,0.001116637,0.00007689232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951488,0.001123538,0.003243228,0.000137692,0.00007505935,0.0001088217,0.00002755052,0.000006197276,0.0001291101],"genre_scores_gemma":[0.9987779,0.0001146255,0.0007137881,0.0001808568,0.00007145999,0.000005207737,0.00008286426,0.000009103179,0.00004416244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01413132,"threshold_uncertainty_score":0.3112656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02767838461893081,"score_gpt":0.2455185666921866,"score_spread":0.2178401820732558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}