{"id":"W3000572934","doi":"10.1074/jbc.ra119.011775","title":"The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"Proprotein Convertases; Furin; Proprotein convertase; Kexin; Endosome; Serine; Cell biology; Signal transducing adaptor protein; Cleavage (geology); Golgi apparatus; Transmembrane protein; Cytosol; Proteases; Biology; Endocytosis; Transmembrane domain; Biochemistry; Receptor; Endoplasmic reticulum; Signal transduction; LDL receptor; Enzyme; Phosphorylation; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007052754,0.0003188085,0.0001388869,0.0001120133,0.000161717,0.0002521367,0.0001298784,0.0002307504,0.001209763],"category_scores_gemma":[0.00009167652,0.00009660693,0.0001759444,0.0001247697,0.0001817034,0.0001692637,0.0001725648,0.0003438191,0.0008095746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395352,"about_ca_system_score_gemma":0.0001251918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003727539,"about_ca_topic_score_gemma":0.0003627915,"domain_scores_codex":[0.999911,0.00001566431,0.000006713105,0.00002062311,0.00002516021,0.00002097394],"domain_scores_gemma":[0.9999409,0.000009265962,0.00001664909,0.0000046723,0.000008775747,0.00001964427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143418,0.000009771884,0.0003852144,0.00002895421,0.000002999958,0.000297158,0.00001278754,0.00009927525,0.9962562,0.0001666691,0.00005834271,0.002539188],"study_design_scores_gemma":[0.00002252472,0.0001801313,0.01672415,0.00001248075,0.00001369344,0.001009329,0.00005539782,0.00174841,0.9744493,0.0001579253,0.005617205,0.000009381258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912883,0.001866031,0.005087484,0.0001067613,0.00002855438,0.0000150054,0.000280561,0.00008247721,0.001244854],"genre_scores_gemma":[0.9941737,0.000550764,0.00193566,0.0000627122,0.00001321529,0.00001116651,0.0005935386,0.00002091846,0.002638289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209763,"threshold_uncertainty_score":0.004047096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308925122174389,"score_gpt":0.2280343925708224,"score_spread":0.2049451413490785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}