{"id":"W3000606865","doi":"10.3389/fgene.2019.01356","title":"The Sole Mycobacterium smegmatis MazF Toxin Targets tRNALys to Impart Highly Selective, Codon-Dependent Proteome Reprogramming","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; York University; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Rutgers, The State University of New Jersey","keywords":"Endoribonuclease; Biology; Mycobacterium smegmatis; Transfer RNA; Ribosome; RNA; Proteome; Start codon; Stop codon; Protein biosynthesis; Genetics; Messenger RNA; Molecular biology; Gene; RNase P","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844976,0.0003094108,0.0003167409,0.0001687251,0.0001634939,0.0004316385,0.0001166664,0.0003423793,0.0005215058],"category_scores_gemma":[0.0002593718,0.0001257795,0.0003209858,0.0001706876,0.0001739291,0.0001799993,0.000266576,0.0004969145,0.0004508946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241954,"about_ca_system_score_gemma":0.0001896702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000428413,"about_ca_topic_score_gemma":0.0008416084,"domain_scores_codex":[0.9998335,0.00001401215,0.00001223148,0.00005291179,0.00005386823,0.00003346844],"domain_scores_gemma":[0.9998876,0.00001933098,0.00003602662,0.00001588253,0.00002114835,0.00002009552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004080394,0.000004253831,0.0002683324,0.00002630812,0.000002479896,0.00001935763,0.00000757338,0.00004767194,0.9986854,0.00002249378,0.0000421505,0.0008330711],"study_design_scores_gemma":[0.000007914152,0.0001562167,0.006646083,0.000009582319,0.00001379737,0.0001893103,0.00003287371,0.001433486,0.9863578,0.00006522442,0.005080259,0.000007506443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898665,0.001549564,0.005416832,0.0001681602,0.00005830645,0.00002360843,0.00170243,0.0003294395,0.0008851219],"genre_scores_gemma":[0.9879078,0.0006125395,0.006610759,0.0001491781,0.00001703298,0.00003919004,0.002570266,0.0001183725,0.001974769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005215058,"threshold_uncertainty_score":0.001755476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671541738870163,"score_gpt":0.2703468687065298,"score_spread":0.2536314513178282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}