{"id":"W3000625420","doi":"10.1007/s40744-019-00190-7","title":"Nonmedical Switching From Originators to Biosimilars: Does the Nocebo Effect Explain Treatment Failures and Adverse Events in Rheumatology and Gastroenterology?","year":2020,"lang":"en","type":"review","venue":"Rheumatology and Therapy","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"AbbVie","keywords":"Nocebo Effect; Biosimilar; Nocebo; Discontinuation; Medicine; Adverse effect; Intensive care medicine; Internal medicine; Alternative medicine; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00179314,0.0005686599,0.001469383,0.002360754,0.0002844352,0.001436844,0.0007689353,0.001721054,0.002280346],"category_scores_gemma":[0.005754133,0.0002725057,0.001327616,0.00205205,0.0007210431,0.001487165,0.0005353612,0.001605915,0.0003701496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008948352,"about_ca_system_score_gemma":0.002632875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628364,"about_ca_topic_score_gemma":0.003120526,"domain_scores_codex":[0.9990517,0.0003487882,0.0002241825,0.0001044005,0.0002275365,0.00004332303],"domain_scores_gemma":[0.9951246,0.003751004,0.0006966913,0.00004631631,0.0003333534,0.00004799664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001826492,0.00005573988,0.0008113091,0.1406105,0.0006682164,0.0003780471,0.0002936595,0.0002923971,0.0003867665,0.005306008,0.01196013,0.8390546],"study_design_scores_gemma":[0.000123122,0.0003473724,0.006148178,0.1657487,0.003398646,0.007664637,0.0008225495,0.0003761384,0.0006773135,0.007722306,0.8068948,0.00007631879],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007043639,0.9994977,0.00002895198,0.0002068948,0.00005309278,0.000002003874,0.000004173045,6.638579e-7,0.0001360704],"genre_scores_gemma":[0.001264427,0.9981866,0.0000684665,0.0002793664,0.0001136705,0.000004664499,0.000007792904,4.941282e-7,0.00007444709],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002360754,"threshold_uncertainty_score":0.009483159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174355441857241,"score_gpt":0.3083887121203034,"score_spread":0.2909531679345793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}