{"id":"W3000670779","doi":"10.1158/1535-7163.targ-19-pl03-01","title":"Abstract PL03-01: Targeting DNA Repair and Defective DNA repair","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Genome instability; DNA repair; DNA damage; Synthetic lethality; Cancer research; Cancer; Immune system; Biology; Medicine; DNA; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005115482,0.001052526,0.0004489648,0.0009580681,0.0002876371,0.001137343,0.001108045,0.001102321,0.04922213],"category_scores_gemma":[0.0001999969,0.0003805874,0.000479289,0.0007828313,0.000391382,0.0005635714,0.0004583538,0.001797577,0.02405036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001535512,"about_ca_system_score_gemma":0.001326686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421473,"about_ca_topic_score_gemma":0.001953247,"domain_scores_codex":[0.9997917,0.00002782645,0.00001267134,0.00003824193,0.0000679782,0.00006168842],"domain_scores_gemma":[0.999843,0.00001789596,0.00002714584,0.0000168164,0.00002391895,0.00007118464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002770947,0.00144715,0.0007059315,0.001396921,0.00007254802,0.001362082,0.00007564231,0.001088522,0.3345167,0.01308083,0.3214592,0.3220235],"study_design_scores_gemma":[0.0007007109,0.00294246,0.004667229,0.0001964477,0.00007305496,0.004322318,0.00003128205,0.001141206,0.1968579,0.001795424,0.787236,0.00003595721],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.127397,0.1428804,0.0323984,0.02265023,0.01345747,0.002000875,0.0255087,0.008718389,0.6249886],"genre_scores_gemma":[0.2763099,0.07983684,0.01558157,0.006023351,0.001546845,0.000834297,0.0231143,0.0008165367,0.5959364],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.04922213,"threshold_uncertainty_score":0.1646644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009671563450140181,"score_gpt":0.2520839499678477,"score_spread":0.2424123865177075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}