{"id":"W3000684857","doi":"10.1016/b978-0-12-817240-7.00003-6","title":"How are genes modified? Crossbreeding, mutagenesis, and CRISPR-Cas9","year":2020,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"CRISPR; Genetics; Mutagenesis; Biology; Crossbreed; Gene; Cas9; Genome editing; Computational biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000499969,0.0004778827,0.0005665551,0.0005138541,0.0002736909,0.001629856,0.0007506337,0.0009915025,0.008012676],"category_scores_gemma":[0.0003837503,0.0003231221,0.0003657803,0.000554776,0.0008439083,0.001332549,0.0005037416,0.002104517,0.005004913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006046232,"about_ca_system_score_gemma":0.0003180281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006926942,"about_ca_topic_score_gemma":0.001409354,"domain_scores_codex":[0.9997392,0.00002542263,0.00001499521,0.00006997111,0.0001272159,0.00002321157],"domain_scores_gemma":[0.9998715,0.00006361547,0.00001512883,0.00001914102,0.00001685572,0.00001378316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009583829,0.00007474799,0.0003661442,0.0006729434,0.00004036315,0.0004001699,0.0001974897,0.001062008,0.342561,0.07437769,0.03725807,0.5428934],"study_design_scores_gemma":[0.00001198192,0.000121185,0.001476339,0.0003403598,0.00006503796,0.00278731,0.0001763761,0.001740696,0.1423189,0.04478885,0.8061121,0.00006086216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.04246749,0.2794823,0.2462858,0.01591691,0.004737966,0.0001171155,0.001274243,0.003568711,0.4061495],"genre_scores_gemma":[0.1294794,0.2038159,0.1291453,0.008717873,0.0006647922,0.000127052,0.001359412,0.001565223,0.525125],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.008012676,"threshold_uncertainty_score":0.0268051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532697385555136,"score_gpt":0.2581335885414877,"score_spread":0.2428066146859363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}