{"id":"W3000699857","doi":"10.1093/ecco-jcc/jjz203.000","title":"OP01 Higher vs. standard adalimumab maintenance regimens in patients with moderately to severely active ulcerative colitis: Results from the SERENE-UC maintenance study","year":2020,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Dosing; Internal medicine; Regimen; Adverse effect; Adalimumab; Clinical endpoint; Maintenance therapy; Clinical trial; Chemotherapy; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003427815,0.0008438907,0.002707582,0.000450663,0.0003246079,0.001208462,0.0008539578,0.001102089,0.003532822],"category_scores_gemma":[0.002425071,0.0002895026,0.002938769,0.0005061537,0.0006818033,0.001081793,0.0005004012,0.002444289,0.0005556889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004215467,"about_ca_system_score_gemma":0.0004745263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004686545,"about_ca_topic_score_gemma":0.001084046,"domain_scores_codex":[0.9983398,0.0009929923,0.0001525739,0.0002023899,0.0001621055,0.0001501031],"domain_scores_gemma":[0.9977102,0.0008309213,0.0005548511,0.0002520931,0.0001261962,0.0005257498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9352396,0.009313653,0.003878541,0.0008167699,0.002520912,0.00005598279,0.0000887704,0.0001962389,0.003336221,0.00005737836,0.0006492492,0.04384678],"study_design_scores_gemma":[0.4283224,0.5134805,0.05062539,0.0001615427,0.003806264,0.000146726,0.0001051449,0.0005323864,0.0007438369,0.0001286341,0.001895292,0.00005193747],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839632,0.01258674,0.0002292524,0.0003368096,0.0001617839,0.0003883304,0.0007257866,0.00003435539,0.001573767],"genre_scores_gemma":[0.9934871,0.002750674,0.0005001053,0.0006283535,0.0004117775,0.0002543241,0.0011038,0.00001001137,0.0008537755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003532822,"threshold_uncertainty_score":0.01812828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008889123393732089,"score_gpt":0.2259537390077794,"score_spread":0.2170646156140473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}