{"id":"W3000709627","doi":"10.1093/cid/ciz1243","title":"Efficacy and Safety of Switching to Dolutegravir/Lamivudine Fixed-Dose 2-Drug Regimen vs Continuing a Tenofovir Alafenamide–Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Phase 3, Randomized, Noninferiority TANGO Study","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"ViiV Healthcare","keywords":"Tenofovir alafenamide; Medicine; Dolutegravir; Regimen; Lamivudine; Adverse effect; Internal medicine; Population; Viral load; Pharmacology; Human immunodeficiency virus (HIV); Immunology; Virus; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001320489,0.0004310852,0.002091783,0.0001929061,0.0001554131,0.00002704317,0.0001754944,0.00009452152,0.0000310705],"category_scores_gemma":[0.005092445,0.0002708957,0.0002591589,0.0005313528,0.0002666234,0.0001286554,0.0001751206,0.0003079167,0.00000329177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008632955,"about_ca_system_score_gemma":0.0002640499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819551,"about_ca_topic_score_gemma":0.0002741447,"domain_scores_codex":[0.9963322,0.000532145,0.001592531,0.0007902379,0.0003307415,0.0004221672],"domain_scores_gemma":[0.9948297,0.003414586,0.0006841899,0.0004341176,0.0002760606,0.0003613561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3440526,0.01268719,0.6305091,0.0005452851,0.0005881953,0.0001523521,0.005048356,0.0001015555,0.001510226,0.00003787719,0.0002733703,0.004493905],"study_design_scores_gemma":[0.553932,0.01325871,0.4190924,0.00585304,0.002163607,0.000008396897,0.001411286,0.002839854,0.0005507184,0.0000513855,0.0001488772,0.0006896767],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926733,0.0004361616,0.000491711,0.0007449918,0.00008106622,0.005343012,0.00005440701,0.0001106444,0.00006471189],"genre_scores_gemma":[0.9985387,0.0001851404,0.0004859137,0.0002399464,0.00006396227,0.0002445791,0.00004546468,0.00004645676,0.0001497852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2114167,"threshold_uncertainty_score":0.9999743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162887313150714,"score_gpt":0.3442438337001976,"score_spread":0.3226149605686905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}