{"id":"W3000709627","doi":"10.1093/cid/ciz1243","title":"Efficacy and Safety of Switching to Dolutegravir/Lamivudine Fixed-Dose 2-Drug Regimen vs Continuing a Tenofovir Alafenamide–Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Phase 3, Randomized, Noninferiority TANGO Study","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"ViiV Healthcare","keywords":"Tenofovir alafenamide; Medicine; Dolutegravir; Regimen; Lamivudine; Adverse effect; Internal medicine; Population; Viral load; Pharmacology; Human immunodeficiency virus (HIV); Immunology; Virus; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001675767,0.001064279,0.001250427,0.0002592131,0.0003352245,0.0008318314,0.0006109934,0.0009987635,0.003470584],"category_scores_gemma":[0.001709275,0.0003849425,0.001873213,0.0002416856,0.0008293723,0.0007750327,0.0003610419,0.001679449,0.0003542218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001049177,"about_ca_system_score_gemma":0.001189634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608174,"about_ca_topic_score_gemma":0.003334848,"domain_scores_codex":[0.9992774,0.0003844653,0.0000522882,0.0001236769,0.0000663387,0.00009580408],"domain_scores_gemma":[0.9987125,0.0002914358,0.0004182173,0.00008841632,0.00005882605,0.0004305259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9600388,0.009579946,0.007219233,0.0003730406,0.001121664,0.00006645562,0.0001284593,0.0003656367,0.003598357,0.00006658839,0.0007662352,0.01667546],"study_design_scores_gemma":[0.7760012,0.1923352,0.02720771,0.00007712776,0.001460973,0.0001306653,0.00007063057,0.000851147,0.0009468101,0.0002060211,0.0006744927,0.00003804783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969475,0.0009498515,0.0001172686,0.0001420774,0.0000492057,0.0005827695,0.0005481218,0.00001628313,0.0006469652],"genre_scores_gemma":[0.9967002,0.0004695798,0.0004125258,0.0003557253,0.00008526203,0.0007415722,0.0006904443,0.000007681505,0.0005369199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003470584,"threshold_uncertainty_score":0.01161021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162887313150714,"score_gpt":0.3442438337001976,"score_spread":0.3226149605686905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}