{"id":"W3000756349","doi":"10.1126/sciadv.aax9318","title":"Modified cyclodextrins as broad-spectrum antivirals","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Respiratory viral infections research","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation Leenaards; École Polytechnique Fédérale de Lausanne","keywords":"Virus; Herpes simplex virus; Virology; Vero cell; Microbiology; In vitro; Broad spectrum; In vivo; Chemistry; Drug; Cytotoxicity; Biology; Pharmacology; Biochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442028,0.0002747701,0.0001314901,0.0001833848,0.0000843082,0.0002564802,0.0001165579,0.0002707617,0.0008885488],"category_scores_gemma":[0.0001111306,0.0001167314,0.0001487533,0.00009474805,0.0001694406,0.0002246294,0.0001787702,0.0003526164,0.0003010598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002214225,"about_ca_system_score_gemma":0.0001052745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941102,"about_ca_topic_score_gemma":0.0002739642,"domain_scores_codex":[0.9999083,0.00002547633,0.000007367178,0.00001931192,0.00002541316,0.00001406715],"domain_scores_gemma":[0.9999409,0.00001519785,0.0000133826,0.000007164722,0.000009640728,0.00001373916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006857063,0.00003232187,0.0001087322,0.00009057159,0.00000889374,0.00007334019,0.00001625418,0.000451389,0.9911665,0.000747647,0.0001677255,0.007068144],"study_design_scores_gemma":[0.00001010186,0.0001749399,0.0003294463,0.000007169546,0.000008814765,0.0001147856,0.000007921332,0.0006303067,0.9889547,0.00007978395,0.009674937,0.000007114247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399132,0.02455861,0.02067751,0.000498063,0.000413369,0.000164883,0.0003456998,0.0002277864,0.01320091],"genre_scores_gemma":[0.9787948,0.006026161,0.00926538,0.000230434,0.00002858158,0.00004339673,0.0001379282,0.00002069104,0.005452587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008885488,"threshold_uncertainty_score":0.002972543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06531965679360534,"score_gpt":0.4029938288529814,"score_spread":0.337674172059376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}