{"id":"W3000780619","doi":"10.1016/j.ebiom.2020.102627","title":"Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease","year":2020,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Ottawa","funders":"Parkinson's Foundation","keywords":"Alzheimer's disease; Disease; Medicine; Computational biology; Bioinformatics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001211403,0.0008510711,0.001101263,0.0007601861,0.0006045817,0.002521958,0.001143969,0.001063674,0.009252107],"category_scores_gemma":[0.0008833279,0.0002450471,0.001229719,0.000540743,0.0008822364,0.001388441,0.001718691,0.002332269,0.002005561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00197772,"about_ca_system_score_gemma":0.001296064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001812661,"about_ca_topic_score_gemma":0.002048398,"domain_scores_codex":[0.9995674,0.00007392831,0.00002384086,0.000120958,0.0001432844,0.00007055406],"domain_scores_gemma":[0.9997695,0.00004906072,0.00004127424,0.00003797795,0.00005404266,0.00004821156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004131199,0.0008697523,0.009453784,0.006330918,0.0009462445,0.001311877,0.0008584938,0.008053338,0.429448,0.1343049,0.04090227,0.3633893],"study_design_scores_gemma":[0.0008447514,0.003409049,0.0346948,0.001684479,0.001357458,0.002491986,0.001207756,0.0409646,0.2716551,0.1249123,0.5164904,0.0002872603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.289942,0.3603493,0.1154707,0.04001473,0.006767889,0.0009307369,0.01028433,0.002353051,0.1738873],"genre_scores_gemma":[0.8279863,0.1161187,0.02458765,0.006143824,0.00080084,0.0005720906,0.004362311,0.000137943,0.0192903],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009252107,"threshold_uncertainty_score":0.03095138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04559406752770349,"score_gpt":0.2764891065484212,"score_spread":0.2308950390207177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}