{"id":"W3000919557","doi":"10.1200/jop.19.00421","title":"Application of the ASCO Value Framework and ESMO Magnitude of Clinical Benefit Scale to Assess the Value of Abiraterone and Enzalutamide in Advanced Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"JCO Oncology Practice","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Health Sciences Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Enzalutamide; Medicine; Abiraterone; Prostate cancer; Clinical trial; Oncology; Internal medicine; Cancer; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04330802,0.001095534,0.002580558,0.01776331,0.0006889697,0.004131996,0.001780842,0.001334733,0.004952925],"category_scores_gemma":[0.1299587,0.0003771276,0.005829146,0.01429806,0.001093122,0.002251473,0.002657546,0.001692941,0.0005055922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005466259,"about_ca_system_score_gemma":0.006821118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009138513,"about_ca_topic_score_gemma":0.01302698,"domain_scores_codex":[0.9445155,0.03368901,0.006276379,0.001453422,0.01316955,0.000896091],"domain_scores_gemma":[0.8890604,0.08114249,0.01546943,0.00182633,0.0107981,0.001703181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.009084145,0.0008598624,0.2872988,0.02811909,0.0154871,0.0006683985,0.0008984508,0.03345441,0.0007337572,0.04696741,0.1098271,0.4666014],"study_design_scores_gemma":[0.00727936,0.005899932,0.5050669,0.0262899,0.01277938,0.002022336,0.001798929,0.09544075,0.001778899,0.1227126,0.2179551,0.0009759656],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3238416,0.1834996,0.07789495,0.02628866,0.001805922,0.02462124,0.1808699,0.0009079169,0.1802703],"genre_scores_gemma":[0.8573275,0.01071912,0.08486147,0.003771261,0.0006929731,0.01279194,0.02801616,0.0001356149,0.001683848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04330802,"threshold_uncertainty_score":0.2290375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0653993345987498,"score_gpt":0.4721282607479003,"score_spread":0.4067289261491505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}