{"id":"W3000922508","doi":"10.1038/s41586-020-1951-3","title":"Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":319,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute of Mental Health; Fogarty International Center; National Institutes of Health","keywords":"In vivo; Human immunodeficiency virus (HIV); Signalling; Latency (audio); NF-κB; Non canonical; Lentivirus; Virology; Chemistry; Biology; Medicine; Cell biology; Computer science; Signal transduction; Genetics; Telecommunications; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009642405,0.0001205493,0.0002165192,0.00004620292,0.00006364109,0.000009846118,0.0001240964,0.0009452815,0.0003539586],"category_scores_gemma":[0.00006315746,0.00009516433,0.00004186919,0.0001260399,0.0000593827,0.00004531459,0.00006781623,0.001753152,0.0005743146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004158565,"about_ca_system_score_gemma":0.00007604175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000334138,"about_ca_topic_score_gemma":0.00002908972,"domain_scores_codex":[0.9991449,0.00009519874,0.0001469754,0.0002751571,0.00004104975,0.0002966936],"domain_scores_gemma":[0.9996989,0.00009232925,0.00002953889,0.00009462333,0.0000293144,0.00005530791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004043078,0.00009247296,0.02457426,0.0001112532,0.0001782216,0.000358259,0.0008189736,0.000009698651,0.9543871,0.0001522554,0.01755262,0.001360573],"study_design_scores_gemma":[0.03898038,0.003812747,0.03851583,0.001546891,0.0003739448,0.001727368,0.001872353,0.0009513875,0.6522493,0.0005690677,0.256963,0.002437675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737335,0.01944088,0.0001048842,0.004300634,0.0001921767,0.000420531,0.0001173569,0.00005233056,0.001637665],"genre_scores_gemma":[0.998433,0.0001835833,0.00006177434,0.0004254161,0.00004183713,0.00001209762,0.00005761121,0.000009786387,0.0007749098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3021378,"threshold_uncertainty_score":0.7616673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008103564110247027,"score_gpt":0.2423992527994498,"score_spread":0.2342956886892028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}