{"id":"W3000948877","doi":"10.1002/glia.23777","title":"Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing","year":2020,"lang":"en","type":"article","venue":"Glia","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University and Génome Québec Innovation Centre; McGill University; Douglas Mental Health University Institute; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Genome Canada","keywords":"Biology; Transcriptome; Oligodendrocyte; Progenitor cell; Gene expression; Stem cell; Cell; RNA; Neural stem cell; Cell biology; Molecular biology; Gene; Genetics; Myelin; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544519,0.0001064601,0.0002322497,0.0007430816,0.0001905921,0.0004305097,0.0001161312,0.0001538734,0.0003911263],"category_scores_gemma":[0.0003132146,0.00009316068,0.0001491114,0.0005153386,0.0001367493,0.00008362465,0.0001362209,0.0001588593,0.0003058559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134433,"about_ca_system_score_gemma":0.0002427114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001784956,"about_ca_topic_score_gemma":0.003022732,"domain_scores_codex":[0.9998693,0.00001136588,0.000007782367,0.00005257396,0.00004062635,0.00001826292],"domain_scores_gemma":[0.9998876,0.00002714319,0.00002446036,0.000009193127,0.00004207289,0.000009587011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001991405,0.00001969922,0.03471616,0.0001204599,0.00003834247,0.0002638276,0.0003888006,0.0004035956,0.9269034,0.0002401145,0.0003383897,0.03636823],"study_design_scores_gemma":[0.00001337032,0.0004019208,0.644973,0.00009368204,0.0001650543,0.002191551,0.00101779,0.007096136,0.3243653,0.0009688928,0.01866591,0.00004738862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793339,0.002846275,0.01135397,0.00006599518,0.00001212759,0.00004918701,0.004951624,0.0001059595,0.00128091],"genre_scores_gemma":[0.9545411,0.003650049,0.03169574,0.0001261746,0.00001846422,0.0002071993,0.007485654,0.00007074953,0.002204878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784956,"threshold_uncertainty_score":0.003549159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05516791664106403,"score_gpt":0.2397655775738578,"score_spread":0.1845976609327938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}