{"id":"W3001161720","doi":"10.1016/j.cjca.2020.01.008","title":"Humanized Monoclonal Antibodies Against IgE Antibodies as Therapy for IgE-Mediated Coronary Syndromes: Are We There Yet?","year":2020,"lang":"en","type":"letter","venue":"Canadian Journal of Cardiology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Immunoglobulin E; Degranulation; Immunology; Antibody; Antigen; Medicine; Mast cell; CD23; Omalizumab; Receptor; Allergy; Monoclonal antibody; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0002895373,0.0007287342,0.002497273,0.0006389525,0.0005104975,0.00005474599,0.000921237,0.001778792,0.0006356626],"category_scores_gemma":[0.0002216818,0.0006176843,0.0009978017,0.0001315085,0.001052665,0.00009291819,0.00004847835,0.002589984,0.0002058726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066277,"about_ca_system_score_gemma":0.001986172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349235,"about_ca_topic_score_gemma":0.0008003596,"domain_scores_codex":[0.9966272,0.0005878189,0.00101254,0.0005608794,0.00009303291,0.001118597],"domain_scores_gemma":[0.9971125,0.0006301912,0.001081777,0.000414646,0.0005448869,0.0002160672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003277986,0.000005528241,0.002785576,0.0001694239,0.003328367,0.006193676,0.0003585352,0.00001398165,0.002154446,0.00004634574,0.9829535,0.001662813],"study_design_scores_gemma":[0.002632172,0.0008969692,0.002431939,0.0002516603,0.0002352328,0.002458911,0.0004105696,8.356337e-7,0.0001230741,0.0003944793,0.9895653,0.0005988484],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.06886493,0.2721749,0.0001842262,0.6212495,0.01621407,0.001890958,0.007934548,0.0001078698,0.01137907],"genre_scores_gemma":[0.4072669,0.07377864,0.000267399,0.4771877,0.01307511,0.000101536,0.01017805,0.0005693267,0.0175753],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.338402,"threshold_uncertainty_score":0.9997111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053896311301149,"score_gpt":0.2390728924518217,"score_spread":0.2085339293388102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}