{"id":"W3001173245","doi":"10.1161/circheartfailure.119.006638","title":"Mechanistic Effects of Spironolactone on Cardiovascular and Renal Biomarkers in Heart Failure With Preserved Ejection Fraction","year":2020,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Spironolactone; Heart failure; Medicine; Internal medicine; Ejection fraction; Natriuretic peptide; Interquartile range; Cardiology; Renal function; Placebo; Uric acid; Aldosterone; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355278,0.0004667611,0.000913002,0.0002595217,0.0002116647,0.0006486439,0.0003393401,0.0004335707,0.0009307475],"category_scores_gemma":[0.001639152,0.0002140497,0.0007821755,0.0003103003,0.0003724014,0.0003453461,0.0003866595,0.0006654905,0.00011203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000363863,"about_ca_system_score_gemma":0.0004916028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009005461,"about_ca_topic_score_gemma":0.001835518,"domain_scores_codex":[0.9993067,0.0004119866,0.00004979766,0.00005947485,0.00008789344,0.00008418889],"domain_scores_gemma":[0.998356,0.000414448,0.0007088499,0.000161824,0.0001465456,0.0002123334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1041556,0.002991363,0.7634777,0.001067547,0.004958062,0.0005198519,0.0002772875,0.001393746,0.04253697,0.0001903273,0.000927917,0.07750354],"study_design_scores_gemma":[0.001802351,0.01061764,0.982275,0.00005631146,0.001261704,0.0002613862,0.00007877475,0.0004081347,0.002156135,0.0001449771,0.0009233071,0.00001431922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892228,0.009462121,0.0001340674,0.0001799143,0.00002399871,0.00003939677,0.0003269025,0.00000703888,0.00060382],"genre_scores_gemma":[0.9982672,0.0009607352,0.0001654333,0.0001488932,0.00006427887,0.00002903666,0.0002585152,0.000001378024,0.0001044926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355278,"threshold_uncertainty_score":0.01245606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603012518932542,"score_gpt":0.2292123553393705,"score_spread":0.2131822301500451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}