{"id":"W3001173245","doi":"10.1161/circheartfailure.119.006638","title":"Mechanistic Effects of Spironolactone on Cardiovascular and Renal Biomarkers in Heart Failure With Preserved Ejection Fraction","year":2020,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Spironolactone; Heart failure; Medicine; Internal medicine; Ejection fraction; Natriuretic peptide; Interquartile range; Cardiology; Renal function; Placebo; Uric acid; Aldosterone; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687979,0.0001615567,0.0004429026,0.0001863719,0.00006374592,0.00001538284,0.00002270255,0.0001623429,0.00003608193],"category_scores_gemma":[0.0001880289,0.0001390504,0.0001254158,0.0003442805,0.00004137402,0.0001493821,0.00001284785,0.0002081134,0.0000131585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007669109,"about_ca_system_score_gemma":0.00005618411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009105192,"about_ca_topic_score_gemma":0.00002713191,"domain_scores_codex":[0.9986767,0.0001145521,0.0002473924,0.0003585073,0.0004524688,0.000150343],"domain_scores_gemma":[0.9993377,0.00008684566,0.00006785503,0.0002200976,0.0001238652,0.0001636568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001434944,0.0001937569,0.1938458,0.000867304,0.000556719,0.00004949411,0.0001919704,0.003811644,0.7956265,0.0002283777,0.001503589,0.001689915],"study_design_scores_gemma":[0.004307865,0.0008958713,0.9224098,0.0005244201,0.0002917774,0.00008364488,0.0001882791,0.02113086,0.02823364,0.00004654008,0.0216571,0.0002301847],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988777,0.0003000475,0.003322016,0.006582906,0.00003042988,0.0008821798,0.000001786624,0.0000576901,0.00004588461],"genre_scores_gemma":[0.9977844,0.00000709868,0.001708978,0.0003235734,0.00009007676,0.00001823985,0.0000368326,0.00002460119,0.000006160259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7673928,"threshold_uncertainty_score":0.567031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603012518932542,"score_gpt":0.2292123553393705,"score_spread":0.2131822301500451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}