{"id":"W3001201582","doi":"10.1161/circulationaha.119.042339","title":"Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Regione Toscana; MyoKardia; Fondation Leducq; National Heart, Lung, and Blood Institute; Ministero della Salute; Sarnoff Cardiovascular Research Foundation; British Heart Foundation; National Center for Advancing Translational Sciences; Wellcome Trust; National Science Foundation; American Heart Association; Howard Hughes Medical Institute; National Institutes of Health","keywords":"Myosin; Sarcomere; Hypertrophic cardiomyopathy; MYH7; Missense mutation; Medicine; Allosteric regulation; Cardiomyopathy; Myocyte; Cell biology; Biophysics; Biochemistry; Internal medicine; Biology; Mutation; Heart failure; Gene; Myosin light-chain kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000257605,0.0002056447,0.0002032907,0.000156845,0.000151343,0.000198958,0.000144773,0.0002114158,0.001286234],"category_scores_gemma":[0.0001852461,0.00008072278,0.00008614478,0.00009544213,0.0002715896,0.000109535,0.0001891057,0.0001856639,0.0001609548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174698,"about_ca_system_score_gemma":0.0001341574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003794634,"about_ca_topic_score_gemma":0.0006523827,"domain_scores_codex":[0.99992,0.00001704518,0.000005862401,0.0000265752,0.00001499646,0.0000155343],"domain_scores_gemma":[0.9998968,0.00001705179,0.00004017065,0.000009522994,0.00001258615,0.00002388022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008234186,0.00005108867,0.03148982,0.00007094726,0.00002428243,0.0001233552,0.00004796294,0.0001523014,0.9609799,0.0001667583,0.0001106659,0.005959474],"study_design_scores_gemma":[0.00009610241,0.001200898,0.8096573,0.00006631955,0.0001507125,0.001470218,0.0001941585,0.003703192,0.1809893,0.0005555511,0.001899555,0.00001662287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968114,0.001686776,0.0007882054,0.0000797223,0.000009102373,0.000009909502,0.0000872832,0.00001456678,0.0005128327],"genre_scores_gemma":[0.9988964,0.0003688383,0.0004335322,0.00002984633,0.000008886785,0.000008228517,0.00005047418,0.000003438442,0.0002003246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286234,"threshold_uncertainty_score":0.004302919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115234299341533,"score_gpt":0.2246713147138098,"score_spread":0.2035189717203944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}