{"id":"W3001266181","doi":"10.1074/jbc.ra119.011469","title":"Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ministry of Technology, Innovation and Citizens' Services; Howard Hughes Medical Institute; Canada Research Chairs; Government of Canada; Canadian Light Source; Canada Foundation for Innovation","keywords":"Teichoic acid; Microbiology; Staphylococcus aureus; Bacteria; Chemistry; Staphylococcus; DNA ligase; Gram-positive bacteria; Biology; Biochemistry; DNA; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005006474,0.0001638134,0.0007181904,0.00006042923,0.00004052799,0.000009930236,0.0003184156,0.000206735,0.0005026542],"category_scores_gemma":[0.0009773325,0.00007435966,0.0007463848,0.0009303004,0.0002184811,0.00003026495,0.00007267611,0.0006373811,0.000001189787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003327744,"about_ca_system_score_gemma":0.00007755328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003162885,"about_ca_topic_score_gemma":2.891103e-7,"domain_scores_codex":[0.9986541,0.00006884646,0.0006418143,0.0002021386,0.0002484564,0.0001846621],"domain_scores_gemma":[0.9986076,0.0001691848,0.0005403146,0.0002126423,0.0002608925,0.0002093144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005192836,0.0001413969,0.005951618,0.0001029531,0.001161436,0.00007558853,0.00004856277,0.000006463641,0.9900973,9.496306e-7,0.001107466,0.0007869412],"study_design_scores_gemma":[0.0005048288,0.0004583883,0.02656062,0.00005194458,0.001585766,0.00004790799,0.0001096989,0.00002152436,0.9657919,0.00003344476,0.004706753,0.0001272472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875362,0.003263439,0.00001357555,0.008752525,0.00002358267,0.00008713055,0.00002527013,0.0000116065,0.0002866921],"genre_scores_gemma":[0.9963539,0.0005773089,0.0003723264,0.002260551,0.0003693361,2.476282e-7,0.00001596883,0.000005779981,0.00004459847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02430546,"threshold_uncertainty_score":0.5503711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204597339908676,"score_gpt":0.2400561674321822,"score_spread":0.2180101940330954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}