{"id":"W3001266181","doi":"10.1074/jbc.ra119.011469","title":"Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ministry of Technology, Innovation and Citizens' Services; Howard Hughes Medical Institute; Canada Research Chairs; Government of Canada; Canadian Light Source; Canada Foundation for Innovation","keywords":"Teichoic acid; Microbiology; Staphylococcus aureus; Bacteria; Chemistry; Staphylococcus; DNA ligase; Gram-positive bacteria; Biology; Biochemistry; DNA; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735139,0.0004793776,0.0005717823,0.0003385055,0.000581336,0.0005145273,0.0007124792,0.000557078,0.001870432],"category_scores_gemma":[0.0004489594,0.0002330596,0.000321749,0.0006052363,0.0002363005,0.0003142321,0.000238675,0.0009767644,0.0003511603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059096,"about_ca_system_score_gemma":0.001289193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01848292,"about_ca_topic_score_gemma":0.01471737,"domain_scores_codex":[0.9998324,0.00001730252,0.000007746995,0.00002702969,0.00009293677,0.00002256704],"domain_scores_gemma":[0.9998127,0.00004131182,0.00002889784,0.00001157912,0.00006761019,0.00003803404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001797007,0.001113688,0.03408617,0.001710591,0.0003666121,0.004121422,0.001128652,0.06515782,0.7786902,0.01013736,0.04302126,0.05866918],"study_design_scores_gemma":[0.0008001692,0.0008344608,0.09602865,0.0002152837,0.0003728958,0.0034895,0.001533943,0.4897431,0.3049896,0.003852558,0.09795348,0.0001864068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741294,0.004492149,0.005210624,0.001194441,0.0001113468,0.0000584771,0.005400507,0.0004962123,0.008906861],"genre_scores_gemma":[0.9657943,0.003182719,0.0136379,0.000247432,0.00004284757,0.00008949649,0.01384225,0.0001564251,0.003006689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01848292,"threshold_uncertainty_score":0.03675067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204597339908676,"score_gpt":0.2400561674321822,"score_spread":0.2180101940330954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}