{"id":"W3001297896","doi":"10.3389/fphys.2019.01585","title":"CRISPR/Cas9-Mediated Vitellogenin Receptor Knockout Leads to Functional Deficiency in the Reproductive Development of Plutella xylostella","year":2020,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Science Foundation of Fujian Province; National Natural Science Foundation of China","keywords":"Vitellogenin; Biology; Diamondback moth; Plutella; Mutant; Genetics; LDL receptor; Gene; Endocrinology; Botany; Lipoprotein; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977846,0.0001522895,0.0002241255,0.00008140341,0.00003037424,0.00000355963,0.0002525552,0.0001237538,0.00001572758],"category_scores_gemma":[0.0001859813,0.0001316499,0.00005095538,0.0003255604,0.00007060905,0.00000229456,0.0001074208,0.0001390963,0.00001369577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002227818,"about_ca_system_score_gemma":0.00007955026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004863386,"about_ca_topic_score_gemma":0.00001054696,"domain_scores_codex":[0.9987391,0.00008991712,0.000318457,0.0004831109,0.0001072337,0.0002621706],"domain_scores_gemma":[0.9995791,0.00002011909,0.00005380128,0.000250506,0.00004394451,0.00005252667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002476704,0.00005902993,0.003057503,0.00002429743,0.00001681687,0.00000111306,0.002337863,0.005129995,0.9760836,0.00000672013,0.01155564,0.001479779],"study_design_scores_gemma":[0.0005204476,0.0003122225,0.02249406,0.00001095268,0.00000692568,0.000002917285,0.001699161,0.0001791762,0.9607564,0.00003217374,0.01373647,0.0002490627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816172,0.00118833,0.0158673,0.0004186328,0.0004702809,0.0002649381,0.00001059566,0.00000667632,0.0001560438],"genre_scores_gemma":[0.9911227,0.00005325282,0.007940161,0.0004959235,0.0001915806,0.00003669812,0.0001055687,0.00001503516,0.00003904408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01943656,"threshold_uncertainty_score":0.5368528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213631235625401,"score_gpt":0.2539186993103428,"score_spread":0.2417823869540888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}