{"id":"W3001385540","doi":"10.1002/advs.201903290","title":"Tailored Lipoprotein‐Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor‐Stimulated Macropinocytosis","year":2020,"lang":"en","type":"article","venue":"Advanced Science","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Science and Technology Commission of Shanghai Municipality; Shanghai Education Development Foundation; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"LRP1; Cancer research; Glioma; Pinocytosis; LDL receptor; Endocytosis; Internalization; Cell biology; Downregulation and upregulation; Receptor; Chemistry; Pharmacology; Lipoprotein; Biology; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008458259,0.0002178883,0.0001726151,0.0000356208,0.0003102621,0.00008292578,0.0004442562,0.00008667105,0.00002993311],"category_scores_gemma":[0.0001977514,0.0002109435,0.00004656896,0.0005857484,0.0005725574,0.00006855743,0.0002686161,0.00008574159,0.000006881681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003128685,"about_ca_system_score_gemma":0.0001331972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001164907,"about_ca_topic_score_gemma":0.0000203941,"domain_scores_codex":[0.9982333,0.00005066112,0.0002242502,0.0008243637,0.0003152785,0.0003521437],"domain_scores_gemma":[0.9990037,0.00001547832,0.0001400917,0.000409765,0.0002403189,0.000190621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706134,0.00001022179,0.0001099619,0.00006220839,0.00001136464,0.000005137574,0.0001913321,0.0005043197,0.9967222,0.00004556127,0.0007672735,0.001299834],"study_design_scores_gemma":[0.0005949959,0.00005539782,0.001369051,0.00004892879,0.00001276599,0.000005898047,0.00009732403,0.0001721169,0.981988,0.0001207786,0.01524616,0.0002886078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929971,0.004163411,0.001384683,0.0006702173,0.0001948638,0.0003828367,0.00005439532,0.00004479409,0.0001077526],"genre_scores_gemma":[0.9896588,0.0002086524,0.009426908,0.0003807274,0.00007931425,0.00001974133,0.00004576648,0.00002282158,0.0001573192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0147342,"threshold_uncertainty_score":0.8602028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181281467142866,"score_gpt":0.2359515396008521,"score_spread":0.2277702581337092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}