{"id":"W3001389567","doi":"10.1158/1078-0432.ccr-19-2485","title":"PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Western University; Princess Margaret Cancer Centre","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Head and neck squamous-cell carcinoma; Mutant; Radioresistance; Cancer research; PI3K/AKT/mTOR pathway; Biology; Downregulation and upregulation; Cell culture; Cell; Cancer; Gene; Cell biology; Signal transduction; Head and neck cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108891,0.0003085645,0.0004145571,0.0004446814,0.0002059408,0.0003840302,0.0002289016,0.0001530386,0.002234231],"category_scores_gemma":[0.000116543,0.0001247249,0.0003112852,0.0003473379,0.0001437092,0.0001535161,0.0002236523,0.0005753891,0.0004528963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005549013,"about_ca_system_score_gemma":0.0005141584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001295344,"about_ca_topic_score_gemma":0.004401559,"domain_scores_codex":[0.9999142,0.000005397962,0.000005078514,0.00001504539,0.00003145505,0.00002877484],"domain_scores_gemma":[0.9999619,0.000004732599,0.000009235957,0.000004764143,0.000006913237,0.0000125389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002352568,0.0007523851,0.004108374,0.0004468323,0.00008505512,0.0001874242,0.0000336772,0.001125426,0.94354,0.0001953131,0.001620778,0.04555216],"study_design_scores_gemma":[0.0004147099,0.004152125,0.06028203,0.00004274269,0.0002261908,0.0007865252,0.0001174486,0.00352336,0.9185228,0.0001984056,0.01171527,0.00001843247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910496,0.003342377,0.0007083809,0.0001297549,0.00004219627,0.0001034266,0.001515964,0.0002264529,0.002881757],"genre_scores_gemma":[0.9944077,0.001633766,0.0006852844,0.00007538046,0.000007433586,0.00008162831,0.001675001,0.00002668582,0.001407059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234231,"threshold_uncertainty_score":0.007474184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176647177057211,"score_gpt":0.4094809852055777,"score_spread":0.2918162674998567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}