{"id":"W3001407138","doi":"10.1182/blood.2019002395","title":"Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Genentech; Servier; Eisai; Celltrion; Incyte; Teva Pharmaceutical Industries; Gilead Sciences; Amgen; Pfizer; MorphoSys; PharmaMar; Celgene; BC Cancer Agency; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Oncology; Medicine; Internal medicine; Refractory (planetary science); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005928037,0.0001727199,0.000549989,0.0002693954,0.0001184212,0.0003707939,0.0001709321,0.000161578,0.0002365985],"category_scores_gemma":[0.0007579308,0.00008780776,0.0001922959,0.0002217971,0.0001393294,0.0001895017,0.0000884931,0.0003266126,0.00007308954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005207096,"about_ca_system_score_gemma":0.0002131819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192211,"about_ca_topic_score_gemma":0.003017358,"domain_scores_codex":[0.9998185,0.00006281347,0.00001545642,0.00002613181,0.00005892367,0.00001817955],"domain_scores_gemma":[0.9996301,0.0001356947,0.0001043579,0.00002064211,0.00004137355,0.00006779462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02937788,0.001525252,0.5122771,0.0002725691,0.0004154635,0.000606131,0.0002757752,0.003494665,0.1040808,0.0001620656,0.0008818085,0.3466305],"study_design_scores_gemma":[0.004062637,0.0400569,0.884308,0.00007584089,0.0007312442,0.002837864,0.0002333982,0.03093836,0.03143368,0.000386785,0.004875957,0.00005922677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977115,0.001740817,0.0001282676,0.00004419125,0.000004048839,0.00002116554,0.0000550853,0.000008746743,0.0002860355],"genre_scores_gemma":[0.9988638,0.0005592885,0.0002918382,0.0000483365,0.000009087539,0.000009956731,0.0001271345,0.000001609303,0.00008895887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192211,"threshold_uncertainty_score":0.003777981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103722430327436,"score_gpt":0.2220598780567124,"score_spread":0.2110226537534381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}