{"id":"W3001407138","doi":"10.1182/blood.2019002395","title":"Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Genentech; Servier; Eisai; Celltrion; Incyte; Teva Pharmaceutical Industries; Gilead Sciences; Amgen; Pfizer; MorphoSys; PharmaMar; Celgene; BC Cancer Agency; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Oncology; Medicine; Internal medicine; Refractory (planetary science); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007724559,0.0001167804,0.0001206241,0.00002643572,0.00003398303,0.00001330365,0.0000911198,0.0001379333,0.00001773313],"category_scores_gemma":[0.00009069384,0.0001120653,0.00003593837,0.0000709628,0.00005347992,0.000003508073,0.00005816072,0.0001147764,0.000008338636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006181374,"about_ca_system_score_gemma":0.00004557619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005848033,"about_ca_topic_score_gemma":0.00000640118,"domain_scores_codex":[0.9992369,0.00005889249,0.0001775294,0.0003054031,0.00008088629,0.0001403181],"domain_scores_gemma":[0.9996603,0.00001101885,0.00005256852,0.0001509732,0.00002120001,0.0001039921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007689584,0.0003857293,0.004997943,0.00001062177,0.00007229318,0.00001005112,0.0002499745,0.00001656768,0.9891891,0.00002579672,0.001210647,0.003062283],"study_design_scores_gemma":[0.01539694,0.001190156,0.02368752,0.0000209985,0.0000288763,0.00001107289,0.00006321056,0.0001809526,0.8843328,0.00003491239,0.07475568,0.0002969097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957448,0.001567558,0.0004817294,0.0007643575,0.00004800325,0.0002664969,0.00002596958,0.00001732753,0.001083717],"genre_scores_gemma":[0.9973423,0.0006549364,0.0004506551,0.001040213,0.0002482667,0.00002031681,0.00006210805,0.00002056331,0.0001605638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1048563,"threshold_uncertainty_score":0.4569891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103722430327436,"score_gpt":0.2220598780567124,"score_spread":0.2110226537534381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}