{"id":"W3001415022","doi":"10.1016/j.jhep.2020.01.007","title":"Hepatocellular carcinoma prediction beyond year 5 of oral therapy in a large cohort of Caucasian patients with chronic hepatitis B","year":2020,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Merck Sharp and Dohme; Gilead Sciences; Novartis; Janssen Biotech; MedImmune; Roche; AbbVie; Merck; Siemens; Bristol-Myers Squibb","keywords":"Medicine; Hepatocellular carcinoma; Internal medicine; Cirrhosis; Entecavir; Gastroenterology; Cumulative incidence; Incidence (geometry); Cohort; Hepatitis B; Chronic hepatitis; Immunology; Lamivudine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545382,0.0002007886,0.0009763522,0.0002711444,0.00002322626,0.000003794182,0.0001183405,0.0001714568,0.0001997668],"category_scores_gemma":[0.00004706195,0.0001518563,0.0002128583,0.0003714458,0.0001049769,0.0001150979,0.00002678305,0.0002911987,0.000003526253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409372,"about_ca_system_score_gemma":0.0004421168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546714,"about_ca_topic_score_gemma":0.0001188206,"domain_scores_codex":[0.9980549,0.000160655,0.0008757099,0.000201018,0.0004260941,0.0002816313],"domain_scores_gemma":[0.9985965,0.00004039803,0.0006036092,0.000184516,0.0003865827,0.0001884275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001625371,0.0006418393,0.9944178,0.0001392589,0.0003509839,0.0004661641,0.0005909333,0.00000109152,0.0007241337,0.00002835484,0.0001670462,0.0008470493],"study_design_scores_gemma":[0.009715355,0.009479412,0.9692116,0.00008963145,0.0002623085,0.0001063158,0.00003676566,0.001648022,0.00880433,0.00001679101,0.0005244798,0.0001050086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972368,0.00121443,0.00008119966,0.0005423907,0.0001054554,0.000611103,0.00005447212,0.000008232291,0.000145853],"genre_scores_gemma":[0.9988461,0.0003488591,0.0005054296,0.000121631,0.00007342659,0.00001023003,0.00005657721,0.00003072487,0.000006991263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02520619,"threshold_uncertainty_score":0.6192521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021858769239791,"score_gpt":0.2257571492467275,"score_spread":0.2038983800069365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}