{"id":"W3001423028","doi":"10.1126/sciadv.aax0021","title":"Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Credit Valley Hospital; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Vlaamse regering; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Lysine; Histone; Histone H3; Cancer; Pathological; Cancer research; Biology; Chemistry; Neuroscience; Medicine; Biochemistry; Genetics; Internal medicine; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009527495,0.00006954223,0.00005851651,0.00002797346,0.0001065303,0.00002237601,0.0001023645,0.00002006108,0.000004736662],"category_scores_gemma":[0.0000636124,0.00006424158,0.000009282873,0.0002160356,0.0002499368,0.00001869506,0.00006221334,0.00003319292,9.2169e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001800412,"about_ca_system_score_gemma":0.00006833068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003339689,"about_ca_topic_score_gemma":0.0001315101,"domain_scores_codex":[0.9992632,0.00001338471,0.0001098207,0.0003208051,0.0001457982,0.0001469565],"domain_scores_gemma":[0.9998047,0.000005420039,0.00004508204,0.00005905684,0.00002562749,0.00006009352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001009049,0.00001303202,0.03735253,0.000007331742,5.834505e-7,9.986293e-8,0.0001627247,0.0007207437,0.9154227,0.00001517303,0.00002817075,0.04626686],"study_design_scores_gemma":[0.0003943586,0.0002141795,0.08020145,0.00001049643,0.000002803725,3.831613e-7,0.0002366973,0.00100814,0.8407319,0.0002168251,0.07674553,0.0002372832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866766,0.01085929,0.001189274,0.0008467644,0.00008507314,0.0001223267,0.000007962079,0.000005364688,0.0002073988],"genre_scores_gemma":[0.9971831,0.001700073,0.0008129329,0.0002196428,0.00001909694,0.0000123625,0.00001632251,0.000004439647,0.00003205801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07671735,"threshold_uncertainty_score":0.2619695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035882243735459,"score_gpt":0.2898924106994523,"score_spread":0.2795335882620977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}