{"id":"W3001480569","doi":"10.1126/sciadv.aax6646","title":"Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute","keywords":"Cholinergic; Agonist; Disease; Function (biology); Neuroscience; Cholinergic system; Medicine; Tropomyosin receptor kinase A; Cell biology; Biology; Receptor; Internal medicine; Nerve growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540684,0.0004631013,0.000351993,0.0004979818,0.0001406701,0.0002059672,0.0002771502,0.0006346739,0.001912595],"category_scores_gemma":[0.0001105085,0.0001886449,0.0003048123,0.0001542193,0.0003439675,0.0002995392,0.0001372114,0.0008689128,0.0004768935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969919,"about_ca_system_score_gemma":0.0002990162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001832667,"about_ca_topic_score_gemma":0.002792675,"domain_scores_codex":[0.9998671,0.00001361252,0.00001604378,0.0000344063,0.00002978631,0.00003900813],"domain_scores_gemma":[0.9999164,0.000008752449,0.00001965627,0.000009695545,0.00001469303,0.00003083055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004262956,0.00007237936,0.00004126861,0.00005081225,0.00000793829,0.00004047175,0.00001860574,0.00003396133,0.9969073,0.00006077134,0.0001500041,0.002190137],"study_design_scores_gemma":[0.00007415994,0.001153194,0.001191739,0.00001134312,0.00004093763,0.0001544407,0.00003963039,0.0004907588,0.9946657,0.0000572554,0.002114632,0.000006226253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884393,0.00265478,0.004510212,0.000425289,0.0002345011,0.00005519307,0.0006388391,0.0003173828,0.002724514],"genre_scores_gemma":[0.9823976,0.002052525,0.003025,0.0002209893,0.00003506616,0.0001147074,0.0006929377,0.00004647625,0.01141472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912595,"threshold_uncertainty_score":0.006398261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153472337098266,"score_gpt":0.2435438835014436,"score_spread":0.2220091601304609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}