{"id":"W3001604492","doi":"10.1038/s41467-020-14299-9","title":"Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Novartis Pharma; Centre Léon Bérard; Ministero dello Sviluppo Economico; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Wellcome Trust; Agence Nationale de la Recherche; Institut National de la Santé et de la Recherche Médicale; Ontario Ministry of Economic Development and Innovation; Merck KGaA; Styrelsen för Internationellt Utvecklingssamarbete; European Federation of Pharmaceutical Industries and Associations; European Commission; Pfizer","keywords":"Chromatin; Virology; Biology; HEPATITIS DELTA; Viral replication; Virus; Histone; Genetics; Hepatitis B virus; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554817,0.00008834907,0.00009672439,0.00001871956,0.0001833884,0.00001073651,0.0007157937,0.0001650515,0.000004120885],"category_scores_gemma":[0.0003974783,0.00007390599,0.00009131632,0.0001011692,0.0001375418,0.000006389888,0.0001869073,0.0001904308,0.00000191146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002340201,"about_ca_system_score_gemma":0.00007197881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004062942,"about_ca_topic_score_gemma":0.000158851,"domain_scores_codex":[0.9992877,0.00009690659,0.0002407671,0.0002015726,0.00008626982,0.00008681119],"domain_scores_gemma":[0.9980878,0.00004188081,0.0001862686,0.001486961,0.0001562365,0.00004088025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003439599,0.00005609152,0.0001145475,0.00001203715,0.00003765425,2.300468e-8,0.0001759124,0.00001881553,0.9571323,0.004555542,0.03134387,0.006518753],"study_design_scores_gemma":[0.0002693265,0.0001313025,0.000669106,0.0000116024,0.00002349083,0.000001022275,0.0000489443,0.002092141,0.6205527,0.0001805449,0.3759189,0.0001008763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7322746,0.05047434,0.04433462,0.1570427,0.0005181385,0.007592982,0.001216109,0.0001689897,0.006377521],"genre_scores_gemma":[0.9735922,0.002210542,0.02067757,0.001929222,0.00008410552,0.0002913646,0.001090031,0.00001494255,0.0001100533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.344575,"threshold_uncertainty_score":0.3013799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04718118833445904,"score_gpt":0.3349844020369928,"score_spread":0.2878032137025337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}