{"id":"W3001655014","doi":"10.1158/1078-0432.ccr-19-1431","title":"First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"AbbVie","keywords":"Medicine; Neutropenia; Leukopenia; Pharmacokinetics; Adverse effect; Internal medicine; Gastroenterology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001114756,0.001223994,0.00116911,0.0003085404,0.0004071999,0.0007249035,0.0006412828,0.0007461737,0.003218035],"category_scores_gemma":[0.0004884581,0.0005277251,0.0007918306,0.0002932657,0.0006125861,0.000612163,0.0002765861,0.002597309,0.000852884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000994341,"about_ca_system_score_gemma":0.001371892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037685,"about_ca_topic_score_gemma":0.003670222,"domain_scores_codex":[0.9996964,0.0001237152,0.00001487321,0.00004905437,0.0000359672,0.00007996089],"domain_scores_gemma":[0.9996372,0.00003970658,0.00008217114,0.00002550316,0.00002773399,0.000187567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4450181,0.1428307,0.01930995,0.001343363,0.00193954,0.000628564,0.0008584916,0.006111741,0.160285,0.0004581701,0.01026251,0.2109539],"study_design_scores_gemma":[0.3133659,0.6426339,0.02316358,0.00004695318,0.0004309375,0.0005874756,0.00008695963,0.001966276,0.01195772,0.000196851,0.005525751,0.00003758702],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933441,0.001725206,0.0005569872,0.0002731695,0.00005605921,0.001726319,0.0007205394,0.0000929531,0.001504842],"genre_scores_gemma":[0.9925042,0.001012375,0.001220123,0.0005363492,0.00007029228,0.001054297,0.001246103,0.00002991806,0.002326473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003218035,"threshold_uncertainty_score":0.01076537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1331445551571781,"score_gpt":0.4959936230890403,"score_spread":0.3628490679318622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}