{"id":"W3001713806","doi":"10.1200/jco.19.02931","title":"Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline <i>BRCA/PALB2</i> Mutation","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":398,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Gemcitabine; Veliparib; Internal medicine; PARP inhibitor; Pancreatic cancer; Clinical endpoint; Population; Oncology; PALB2; Surgery; Randomized controlled trial; Gastroenterology; Cancer; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002853716,0.002091127,0.002902299,0.0004517684,0.0005894391,0.001149592,0.001132183,0.001455578,0.004118723],"category_scores_gemma":[0.002260204,0.001112141,0.001353484,0.0004669331,0.001679664,0.001066357,0.000597846,0.002944151,0.0006695779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008237333,"about_ca_system_score_gemma":0.002238247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007240312,"about_ca_topic_score_gemma":0.001823534,"domain_scores_codex":[0.9986923,0.000881766,0.00006581302,0.000171627,0.00006185493,0.0001265784],"domain_scores_gemma":[0.998529,0.0003246898,0.0003347213,0.000120458,0.00006626701,0.0006248613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9630839,0.01785591,0.001718905,0.0002500118,0.0005236894,0.00006655022,0.00006958053,0.0008772983,0.004503647,0.0001417312,0.0008713827,0.01003746],"study_design_scores_gemma":[0.9328727,0.06452271,0.001057173,0.00001012524,0.0001530425,0.00003405253,0.00001348352,0.0004878712,0.0003402509,0.000103502,0.0003956529,0.000009369332],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984322,0.001868981,0.001072545,0.0007913492,0.0003894427,0.009192317,0.0007865969,0.0000809793,0.001495819],"genre_scores_gemma":[0.9805437,0.001369507,0.003010238,0.001546299,0.0004125267,0.009533178,0.00111853,0.00002603681,0.002439943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004118723,"threshold_uncertainty_score":0.01509207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106064802960647,"score_gpt":0.4575294089187974,"score_spread":0.3514646059581503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}