{"id":"W3001713806","doi":"10.1200/jco.19.02931","title":"Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline <i>BRCA/PALB2</i> Mutation","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":398,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Gemcitabine; Veliparib; Internal medicine; PARP inhibitor; Pancreatic cancer; Clinical endpoint; Population; Oncology; PALB2; Surgery; Randomized controlled trial; Gastroenterology; Cancer; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003228339,0.0001877956,0.0036152,0.0001487758,0.00004117404,0.000006707439,0.00008822211,0.0002736123,0.00006368016],"category_scores_gemma":[0.007244245,0.00009951303,0.0001266011,0.0001947255,0.0007655461,0.0001283325,0.00006563514,0.0008129468,8.524709e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004471001,"about_ca_system_score_gemma":0.001187667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004873756,"about_ca_topic_score_gemma":0.0000638831,"domain_scores_codex":[0.9956747,0.0008851802,0.002443141,0.0002634595,0.0004926454,0.000240876],"domain_scores_gemma":[0.9931508,0.003880562,0.001760876,0.0001257044,0.0005554584,0.0005265888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6174369,0.003105147,0.367241,0.00007310721,0.0003991972,0.0002759562,0.0003923167,0.000001149115,0.000009679005,0.000007455561,0.00005027954,0.01100775],"study_design_scores_gemma":[0.6992275,0.1418532,0.1550363,0.0001892266,0.001166328,0.0001098327,0.00013107,0.002028009,0.000007064205,0.00001401798,0.0001608211,0.00007651788],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938505,0.0003081806,0.0003507391,0.003665299,0.00008763449,0.001553416,0.000007151137,0.000004867225,0.0001721872],"genre_scores_gemma":[0.9890561,0.000403435,0.009238716,0.000861527,0.0003393499,0.00002000603,0.000008643446,0.0000185177,0.0000537283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2122047,"threshold_uncertainty_score":0.867256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106064802960647,"score_gpt":0.4575294089187974,"score_spread":0.3514646059581503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}