{"id":"W3001714370","doi":"10.1158/0008-5472.can-19-1704","title":"The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma","year":2020,"lang":"en","type":"letter","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Cancer Institute","keywords":"BAP1; Cancer research; Deubiquitinating enzyme; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Hippo signaling pathway; Suppressor; Biology; Adenocarcinoma; Tumor suppressor gene; SKP2; Ubiquitin; Cancer; Carcinogenesis; Ubiquitin ligase; Medicine; Pancreatic ductal adenocarcinoma; Internal medicine; Signal transduction; Cell biology; Melanoma; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005812994,0.0003096036,0.0002917817,0.00007170808,0.0004026581,0.0001863862,0.001445433,0.0004115683,0.00006590471],"category_scores_gemma":[0.0002579975,0.0001882922,0.0001700436,0.0002774384,0.0005852325,0.0000036776,0.0006446503,0.002363066,0.00004179253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001194839,"about_ca_system_score_gemma":0.0007143352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004120243,"about_ca_topic_score_gemma":0.0004231393,"domain_scores_codex":[0.9967327,0.0006964661,0.0003296344,0.0007418598,0.0005529852,0.0009463642],"domain_scores_gemma":[0.9983405,0.0002217264,0.0000940855,0.001066811,0.0001960211,0.00008079064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009277985,0.000009870128,0.0007368245,0.0001175591,0.00009963821,0.0002492241,0.0001029739,0.000003903192,0.1898949,0.00001750466,0.8084209,0.0002539443],"study_design_scores_gemma":[0.0002958663,0.0001370165,0.0006351056,0.00008775717,0.00001781393,0.00003749452,0.0001281258,0.00003228303,0.106514,0.0002262929,0.8916244,0.000263835],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5059648,0.02598576,0.000003084161,0.4657839,0.0003873262,0.001146442,0.0002531885,0.00001375694,0.0004618093],"genre_scores_gemma":[0.6807069,0.009620463,0.00003897643,0.2641057,0.01712442,0.003005144,0.001489229,0.0003836425,0.02352553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2016782,"threshold_uncertainty_score":0.9999385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076934811823723,"score_gpt":0.3040814355350087,"score_spread":0.2733120874167715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}