{"id":"W3001714370","doi":"10.1158/0008-5472.can-19-1704","title":"The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma","year":2020,"lang":"en","type":"letter","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Cancer Institute","keywords":"BAP1; Cancer research; Deubiquitinating enzyme; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Hippo signaling pathway; Suppressor; Biology; Adenocarcinoma; Tumor suppressor gene; SKP2; Ubiquitin; Cancer; Carcinogenesis; Ubiquitin ligase; Medicine; Pancreatic ductal adenocarcinoma; Internal medicine; Signal transduction; Cell biology; Melanoma; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246596,0.000623446,0.0007107909,0.0004665104,0.001105814,0.001236985,0.0009043674,0.01832581,0.00228692],"category_scores_gemma":[0.003959625,0.0003565552,0.0004613819,0.0003296926,0.001598313,0.00117395,0.0008024635,0.01035655,0.002953222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002700225,"about_ca_system_score_gemma":0.000883295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001635442,"about_ca_topic_score_gemma":0.0025304,"domain_scores_codex":[0.9993396,0.0001332762,0.00006036178,0.0001078849,0.0002716315,0.00008710659],"domain_scores_gemma":[0.9984711,0.0008214925,0.0001235645,0.00007617344,0.0003060456,0.0002016455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004733305,0.00006292755,0.001232666,0.0001972958,0.00003727253,0.01196603,0.0001026371,0.0002448789,0.006243873,0.005776344,0.9432232,0.03043951],"study_design_scores_gemma":[0.000540642,0.0002645763,0.005192807,0.0003308329,0.0000743531,0.01187751,0.000183794,0.001504939,0.006120892,0.02112348,0.9526982,0.00008802526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.005296047,0.02499594,0.0006253903,0.8994811,0.05988792,0.00004703807,0.000180204,0.000156015,0.009330409],"genre_scores_gemma":[0.06950732,0.02398426,0.0006698176,0.6806838,0.1839134,0.0001431857,0.0001369525,0.00009681849,0.04086447],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01832581,"threshold_uncertainty_score":0.01959157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076934811823723,"score_gpt":0.3040814355350087,"score_spread":0.2733120874167715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}