{"id":"W3001748757","doi":"10.1136/jclinpath-2020-206431","title":"Gene of the month: GLI-1","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Biology; Cancer research; Hedgehog; Hedgehog signaling pathway; Transcription factor; GLI1; Gene; HMGA2; Metastasis; PTCH1; Zinc finger; Pathology; Cancer; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006615149,0.0002378363,0.000212285,0.0004141935,0.0004045887,0.0004220371,0.000282108,0.0005494925,0.02099669],"category_scores_gemma":[0.0003789956,0.00008413087,0.0001935772,0.0003558653,0.0002767293,0.0002777946,0.0003625885,0.0004954183,0.01098137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402623,"about_ca_system_score_gemma":0.0003404664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007093922,"about_ca_topic_score_gemma":0.0005302186,"domain_scores_codex":[0.9998932,0.00000805765,0.000006345213,0.00003368178,0.00003854475,0.00002021438],"domain_scores_gemma":[0.9997957,0.00001999667,0.00004060179,0.00001298778,0.00004051696,0.00009008923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001659679,0.0001272927,0.01919736,0.0005647716,0.00007275624,0.01541782,0.0004486365,0.0001771346,0.6106624,0.01592527,0.07966958,0.2560773],"study_design_scores_gemma":[0.00009226118,0.0003513338,0.04944915,0.00009190254,0.00006824656,0.04181203,0.0003115225,0.0007681166,0.1570814,0.003357502,0.7465628,0.00005370473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7009476,0.01695322,0.0338034,0.01731499,0.008858277,0.0003394211,0.02411474,0.003987363,0.1936809],"genre_scores_gemma":[0.6582825,0.003317969,0.009397401,0.002055242,0.0007270341,0.0001261905,0.01042648,0.0005202309,0.315147],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02099669,"threshold_uncertainty_score":0.07024091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08668899513682483,"score_gpt":0.369809128812451,"score_spread":0.2831201336756262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}