{"id":"W3001754065","doi":"10.1016/j.freeradbiomed.2020.01.021","title":"Increased mitochondrial content and function by resveratrol and select flavonoids protects against benzo[a]pyrene-induced bioenergetic dysfunction and ROS generation in a cell model of neoplastic transformation","year":2020,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Mitochondrion; Mitochondrial biogenesis; Resveratrol; Intracellular; Chemistry; Biochemistry; Superoxide; Mitochondrial ROS; Polyphenol; Benzo(a)pyrene; Cell biology; Carcinogen; Biology; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683042,0.0002252545,0.0005816443,0.0001650665,0.00009713939,0.000006077588,0.00003374821,0.0003362765,0.000009343894],"category_scores_gemma":[0.0004300622,0.0001559793,0.00002393009,0.0001669749,0.0004182815,0.00007770024,0.00002144597,0.0003579041,1.881242e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002425976,"about_ca_system_score_gemma":0.00007160019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001733796,"about_ca_topic_score_gemma":0.00005295515,"domain_scores_codex":[0.9985813,0.0001365618,0.0004974799,0.000401016,0.0001656673,0.0002180024],"domain_scores_gemma":[0.9992692,0.0001015372,0.0001113916,0.0001083653,0.00006783719,0.0003416686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002187339,0.00006480351,0.001280496,0.0002557763,0.00004648362,0.000006213846,0.0006975868,0.00002924134,0.9871285,0.0001093404,0.0006792158,0.007514996],"study_design_scores_gemma":[0.06889195,0.02753851,0.007891248,0.0005633684,0.0008839475,0.0001475093,0.0007812214,0.772164,0.1193687,0.0004583153,0.0007686891,0.000542547],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808174,0.004415723,0.007894037,0.005792566,0.0001537344,0.0008365667,0.00002044027,0.00002543807,0.00004406597],"genre_scores_gemma":[0.9955053,0.001795225,0.0002570888,0.001626594,0.0004954565,0.00004567129,0.0002496711,0.00001351122,0.00001144139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8677598,"threshold_uncertainty_score":0.636065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840256753620036,"score_gpt":0.238415136168187,"score_spread":0.2100125686319866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}