{"id":"W3001754065","doi":"10.1016/j.freeradbiomed.2020.01.021","title":"Increased mitochondrial content and function by resveratrol and select flavonoids protects against benzo[a]pyrene-induced bioenergetic dysfunction and ROS generation in a cell model of neoplastic transformation","year":2020,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Mitochondrion; Mitochondrial biogenesis; Resveratrol; Intracellular; Chemistry; Biochemistry; Superoxide; Mitochondrial ROS; Polyphenol; Benzo(a)pyrene; Cell biology; Carcinogen; Biology; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706131,0.0003522505,0.000395953,0.0003306873,0.0002273781,0.0002432542,0.0002774582,0.0003925281,0.001558789],"category_scores_gemma":[0.0001284095,0.0001882368,0.0003162813,0.0002545828,0.0002745258,0.0003669663,0.0001697223,0.0006465492,0.0002424745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002782325,"about_ca_system_score_gemma":0.0002596316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112319,"about_ca_topic_score_gemma":0.001763301,"domain_scores_codex":[0.9998605,0.00002782412,0.00001420637,0.00002831403,0.00002761955,0.0000414481],"domain_scores_gemma":[0.9998996,0.00001024903,0.00002750361,0.00001763205,0.00001531494,0.00002973611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001252133,0.0001150916,0.000198199,0.00002190836,0.00001442243,0.00002158185,0.00002081783,0.00004873724,0.9973053,0.00006139064,0.00003558192,0.00090495],"study_design_scores_gemma":[0.00005177138,0.001421158,0.004873451,0.000004955893,0.00006167476,0.00008936518,0.00005398477,0.0005719566,0.9919137,0.00006043615,0.0008904613,0.000006992023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967309,0.001241307,0.001151106,0.00009388419,0.00003372596,0.00001884127,0.0001973627,0.00005084902,0.0004819523],"genre_scores_gemma":[0.9972998,0.0004767893,0.0005367615,0.0000294514,0.00000655681,0.00001783455,0.0003302009,0.00001002083,0.001292625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558789,"threshold_uncertainty_score":0.005214632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840256753620036,"score_gpt":0.238415136168187,"score_spread":0.2100125686319866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}