{"id":"W3001936787","doi":"10.3390/cells9020275","title":"Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Fundamental Research Funds for the Central Universities; National Institute of General Medical Sciences; National Natural Science Foundation of China","keywords":"Endoplasmic reticulum; HEK 293 cells; Cell biology; Inositol; Calcium signaling; Inositol trisphosphate receptor; STIM1; ORAI1; Receptor; Calcium; Chemistry; Ryanodine receptor; Voltage-dependent calcium channel; Biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108599,0.0002485945,0.0004059386,0.00008360782,0.00006325914,0.0000301585,0.0004005445,0.0002224858,0.0006477515],"category_scores_gemma":[0.0001782344,0.0002302546,0.0001047442,0.000897089,0.0001831867,0.0001093293,0.0001231046,0.0003067755,0.0005037806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007107613,"about_ca_system_score_gemma":0.0001017733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007036835,"about_ca_topic_score_gemma":0.00000511557,"domain_scores_codex":[0.9979391,0.0001353684,0.0005274461,0.0005755478,0.0003872824,0.0004352417],"domain_scores_gemma":[0.9990904,0.0001715679,0.0002312345,0.0001850114,0.00007021945,0.0002515668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001291328,0.00009354523,0.00007780945,0.00005987312,0.000004280719,0.00001104363,0.001080384,0.00006104623,0.9473987,0.00003424773,0.05089904,0.0001509168],"study_design_scores_gemma":[0.0006959836,0.0001667756,0.00000653908,0.00003639688,0.000008984107,0.000001121612,0.000143255,0.01092703,0.9726949,0.00001464563,0.01505752,0.0002468305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942275,0.0001347255,0.00005726624,0.001578018,0.002711498,0.0004434664,0.0003512558,0.00006880192,0.000427455],"genre_scores_gemma":[0.9968936,0.0003602386,0.0001302171,0.001210671,0.0001363258,0.000007878835,0.00002346322,0.0000475353,0.001190036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03584152,"threshold_uncertainty_score":0.938951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995252717667891,"score_gpt":0.2344837158777767,"score_spread":0.2145311887010978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}