{"id":"W3001964195","doi":"10.1172/jci.insight.122312","title":"Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; Arthritis Foundation; Baxter International Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Institutes of Health; National Science Foundation","keywords":"Transcriptome; Gene signature; Immunology; Biomarker; Immune system; Lupus erythematosus; Disease; Pathogenesis; Gene; Systemic lupus erythematosus; Autoimmune disease; Medicine; microRNA; Inflammation; Biology; Gene expression; Antibody; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004562924,0.0003683926,0.001648881,0.0006236704,0.00006219194,0.00003126378,0.0003919985,0.0003893544,0.000398495],"category_scores_gemma":[0.000843345,0.0002688331,0.0005412208,0.003291211,0.0001348525,0.000103823,0.0001336221,0.0006342258,0.0001811121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007091,"about_ca_system_score_gemma":0.0002887753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006471152,"about_ca_topic_score_gemma":0.000009776348,"domain_scores_codex":[0.996434,0.000261229,0.001094525,0.000655624,0.001071695,0.0004828641],"domain_scores_gemma":[0.9971812,0.0003070997,0.0003600934,0.0009184079,0.0007132174,0.0005199917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115485,0.0003785039,0.7292374,0.005969431,0.005488666,0.0009051626,0.01632908,0.0001517949,0.2257646,0.001049412,0.01318613,0.0003850489],"study_design_scores_gemma":[0.080071,0.009434328,0.03224189,0.03844627,0.04864343,0.1361143,0.135755,0.1317206,0.3056258,0.0007682044,0.07207539,0.009103623],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847495,0.004181335,0.00131498,0.0009019356,0.0002674528,0.001394636,0.00005035445,0.0002103534,0.006929484],"genre_scores_gemma":[0.995387,0.0002119896,0.0008628709,0.0003481857,0.0001995906,0.0000565902,0.0001049194,0.00006743619,0.002761385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6969955,"threshold_uncertainty_score":0.9999764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03195911558744839,"score_gpt":0.287338585931492,"score_spread":0.2553794703440436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}