{"id":"W3001964195","doi":"10.1172/jci.insight.122312","title":"Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; Arthritis Foundation; Baxter International Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Institutes of Health; National Science Foundation","keywords":"Transcriptome; Gene signature; Immunology; Biomarker; Immune system; Lupus erythematosus; Disease; Pathogenesis; Gene; Systemic lupus erythematosus; Autoimmune disease; Medicine; microRNA; Inflammation; Biology; Gene expression; Antibody; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008046159,0.0002789347,0.0005892099,0.001190149,0.0002246596,0.0008190622,0.0001505529,0.0002330181,0.0006898002],"category_scores_gemma":[0.0007667997,0.0001571204,0.0005278335,0.001013118,0.000243994,0.0002761655,0.0006121426,0.0003813286,0.0001862895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002287975,"about_ca_system_score_gemma":0.000296817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003391773,"about_ca_topic_score_gemma":0.0009107253,"domain_scores_codex":[0.9993941,0.00009066175,0.00004981864,0.0002232665,0.0001473047,0.00009490457],"domain_scores_gemma":[0.9993788,0.0001748946,0.0001858719,0.00007744696,0.0001066261,0.00007632526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00110033,0.000112199,0.1909924,0.0002165497,0.0004951282,0.0002662299,0.0002444631,0.0009203586,0.7802983,0.000224231,0.0003923794,0.02473751],"study_design_scores_gemma":[0.00003818109,0.0007815681,0.9241048,0.00003434567,0.0004790359,0.001122728,0.0004159571,0.005810262,0.06340355,0.001025197,0.002733266,0.00005114752],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991314,0.0009763848,0.004586027,0.00005690801,0.00001280012,0.00004220776,0.002516957,0.00007033451,0.0004245093],"genre_scores_gemma":[0.9861512,0.0004643179,0.008078059,0.0001838778,0.00002701791,0.00009714493,0.004503161,0.00004055903,0.0004547205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190149,"threshold_uncertainty_score":0.004255295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03195911558744839,"score_gpt":0.287338585931492,"score_spread":0.2553794703440436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}