{"id":"W3002003835","doi":"10.1021/acscatal.9b05011","title":"α-Amino Radicals via Photocatalytic Single-Electron Reduction of Imine Derivatives","year":2020,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Royal Commission for the Exhibition of 1851; Engineering and Physical Sciences Research Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Leverhulme Trust; Astex Pharmaceuticals; AstraZeneca","keywords":"Imine; Umpolung; Chemistry; Iminium; Radical; Electrophile; Photoredox catalysis; Combinatorial chemistry; Amine gas treating; Reductive amination; Organocatalysis; Amination; Radical ion; Photochemistry; Photocatalysis; Organic chemistry; Catalysis; Enantioselective synthesis; Nucleophile; Ion","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005973517,0.0002224417,0.0004280851,0.00006426804,0.0000646847,0.00001929021,0.0003430872,0.0001657259,0.0007029067],"category_scores_gemma":[0.0006687773,0.00022217,0.0002150485,0.000638632,0.0002831332,0.0001767439,0.00008015214,0.0003089437,0.00006336929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001382868,"about_ca_system_score_gemma":0.00005086877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000987337,"about_ca_topic_score_gemma":0.00000170302,"domain_scores_codex":[0.9983069,0.00001638357,0.0005111246,0.0004736224,0.0003811557,0.0003108513],"domain_scores_gemma":[0.9987655,0.0001620054,0.0002535793,0.0004667621,0.0000699291,0.0002821799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006037183,0.0002197593,0.00003565621,0.00009965859,0.0001978918,0.00000336788,0.0003088661,0.00001530684,0.9945318,0.00001907877,0.000530233,0.003977972],"study_design_scores_gemma":[0.0003015206,0.00005670718,0.00002820968,0.00002326164,0.000232639,0.00001635129,0.0001222962,0.0004854916,0.995701,0.0001983204,0.0026296,0.000204634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914601,0.000203639,0.0007219387,0.001060916,0.0000249194,0.0001359263,0.00002544373,0.0001410238,0.006226032],"genre_scores_gemma":[0.9986241,0.00002570831,0.0002728538,0.00009639245,0.0001928395,0.00005034461,0.0003830507,0.00003695233,0.0003177464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007163951,"threshold_uncertainty_score":0.9059829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038444204167011,"score_gpt":0.2495452686549562,"score_spread":0.2291608266132861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}