{"id":"W3002003835","doi":"10.1021/acscatal.9b05011","title":"α-Amino Radicals via Photocatalytic Single-Electron Reduction of Imine Derivatives","year":2020,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Radical Photochemical Reactions","field":"Chemistry","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Royal Commission for the Exhibition of 1851; Engineering and Physical Sciences Research Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Leverhulme Trust; Astex Pharmaceuticals; AstraZeneca","keywords":"Imine; Umpolung; Chemistry; Iminium; Radical; Electrophile; Photoredox catalysis; Combinatorial chemistry; Amine gas treating; Reductive amination; Organocatalysis; Amination; Radical ion; Photochemistry; Photocatalysis; Organic chemistry; Catalysis; Enantioselective synthesis; Nucleophile; Ion","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447258,0.0004412195,0.0002171523,0.000198444,0.0001432,0.0002768267,0.0004545932,0.0003702099,0.001711811],"category_scores_gemma":[0.0001913521,0.0001638252,0.0002097519,0.0001495169,0.000219472,0.0004896559,0.0002623501,0.0006907267,0.0005571348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608083,"about_ca_system_score_gemma":0.0001496339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075306,"about_ca_topic_score_gemma":0.0005369815,"domain_scores_codex":[0.9998677,0.00001356049,0.000009858348,0.00003454329,0.00003651332,0.00003785136],"domain_scores_gemma":[0.9999363,0.00001415166,0.0000187538,0.00001001895,0.00001150585,0.000009240822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005182445,0.00005383024,0.00005854942,0.0002308059,0.00001251401,0.0001923994,0.0001098843,0.0005635354,0.9835323,0.003143824,0.0004914848,0.01155905],"study_design_scores_gemma":[0.00001341357,0.0001838121,0.0001506871,0.000006829016,0.000007942085,0.0001463129,0.00001172436,0.0009405906,0.9923602,0.0002003726,0.005969064,0.000009053968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9202602,0.009177159,0.03314163,0.0006998699,0.0004355308,0.0001643974,0.0002880195,0.0005654555,0.03526773],"genre_scores_gemma":[0.98033,0.003774052,0.008256591,0.0001056757,0.00005518043,0.00004338678,0.000111382,0.00004691623,0.007276823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711811,"threshold_uncertainty_score":0.005726576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038444204167011,"score_gpt":0.2495452686549562,"score_spread":0.2291608266132861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}