{"id":"W3002019744","doi":"10.1101/2020.01.22.916254","title":"p.E152K-STIM1 mutation deregulates Ca <sup>2+</sup> signaling contributing to chronic pancreatitis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Western University","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Natural Sciences and Engineering Research Council of Canada; Association Vaincre la Mucoviscidose; Heart and Stroke Foundation of Canada","keywords":"SERCA; Endoplasmic reticulum; Intracellular; Cell biology; STIM1; Calcium signaling; Calcium in biology; Calcium metabolism; HEK 293 cells; Biology; Crosstalk; Chemistry; Calcium; Internal medicine; ATPase; Biochemistry; Medicine; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445311,0.0005543805,0.0002427586,0.0003521785,0.0002036026,0.0002548059,0.0001546496,0.0005018828,0.00238456],"category_scores_gemma":[0.0002231449,0.0001062965,0.0003142644,0.0002532334,0.0003896454,0.0001137843,0.0003276693,0.0002964273,0.0004147111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001920461,"about_ca_system_score_gemma":0.0001371588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000374651,"about_ca_topic_score_gemma":0.0004120458,"domain_scores_codex":[0.9998887,0.00001951634,0.00002428478,0.00002819379,0.00001995682,0.00001935889],"domain_scores_gemma":[0.999879,0.00002673219,0.00004359927,0.000009852021,0.000009028531,0.00003169629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001055298,0.0001229231,0.03685862,0.00008683115,0.00009417795,0.03667049,0.0001910359,0.0004934868,0.9177936,0.0005728122,0.0004957831,0.005564997],"study_design_scores_gemma":[0.0001880832,0.000968074,0.3607906,0.00008580444,0.0002831978,0.1858232,0.0004231518,0.005428381,0.4325119,0.001275352,0.0121603,0.00006173482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984054,0.0001553094,0.0004419342,0.00007375734,0.00001190328,0.00001240683,0.0003018812,0.00001731454,0.0005800452],"genre_scores_gemma":[0.9986212,0.000110678,0.0003417496,0.0000571942,0.0000102201,0.000007177164,0.0002984313,0.0000109838,0.0005422466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00238456,"threshold_uncertainty_score":0.007977188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959244653348129,"score_gpt":0.2332857478049424,"score_spread":0.2136933012714611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}