{"id":"W3002025258","doi":"10.7554/elife.52611","title":"Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Johns Hopkins University; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Stop codon; Ribosome; Ribosome profiling; Biology; Genetics; Start codon; Gene; Translation (biology); Codon usage bias; Protein biosynthesis; Genome; Messenger RNA; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035387,0.0002480359,0.0003145894,0.0001411796,0.00009992735,0.0004343482,0.0001362318,0.0002626497,0.00103197],"category_scores_gemma":[0.0002298111,0.000152341,0.0001712301,0.0001267184,0.0002006729,0.000130465,0.0002049279,0.000443026,0.0002652048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002846935,"about_ca_system_score_gemma":0.0001504308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004540925,"about_ca_topic_score_gemma":0.001166653,"domain_scores_codex":[0.9998146,0.00003915718,0.00001775172,0.00004889529,0.00004259123,0.00003706712],"domain_scores_gemma":[0.9997965,0.00006759304,0.00006524233,0.00001775673,0.00001729439,0.00003571914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005299827,0.000007848297,0.00009600208,0.00001056265,0.000001669941,0.000008288608,0.000003077975,0.00002453174,0.9994774,0.00001640181,0.000008530214,0.0002927034],"study_design_scores_gemma":[0.000006798934,0.000149717,0.004104884,0.000003600176,0.000008398358,0.00005067433,0.00001629171,0.0004919562,0.9943739,0.00001866929,0.0007716431,0.000003511158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961076,0.0008801325,0.001505285,0.0000605587,0.00002269287,0.00001671833,0.0003580859,0.0000581353,0.0009907541],"genre_scores_gemma":[0.9965351,0.0004595265,0.001613409,0.00005603825,0.000005358282,0.00001437034,0.0004587758,0.00003768385,0.000819762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103197,"threshold_uncertainty_score":0.003452241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851998534970955,"score_gpt":0.2489829082586437,"score_spread":0.2304629229089342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}