{"id":"W3002143230","doi":"10.3390/ijms21030733","title":"Genome Editing for the Understanding and Treatment of Inherited Cardiomyopathies","year":2020,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Muscular Dystrophy Canada; University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Transcription activator-like effector nuclease; Genome editing; Zinc finger nuclease; CRISPR; Duchenne muscular dystrophy; Cardiomyopathy; Biology; Genome; Computational biology; Genome engineering; Muscle disease; Genetics; Bioinformatics; Medicine; Disease; Gene; Heart failure; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220637,0.0001143367,0.0003078129,0.0000839872,0.00004198726,0.00004532934,0.000312256,0.00005114892,9.015563e-7],"category_scores_gemma":[0.00007342202,0.00007119025,0.0002789387,0.00007013784,0.0001186634,0.000003216959,0.00005244129,0.00004014574,6.372174e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003282355,"about_ca_system_score_gemma":0.0001274596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000168931,"about_ca_topic_score_gemma":0.000001008561,"domain_scores_codex":[0.9992635,0.00002667674,0.0002985601,0.0001231095,0.0002109547,0.00007714442],"domain_scores_gemma":[0.999468,0.00005562007,0.0002902808,0.00005659846,0.00009765892,0.00003181558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002927553,0.0000328754,0.00001672442,0.0005029648,0.00189813,0.00005459752,0.0002824088,0.001171607,0.01875073,0.0004477422,0.000033235,0.9767797],"study_design_scores_gemma":[0.0002704592,0.0006738597,0.000008554347,0.0005838796,0.0003322875,0.0004393292,0.0003694037,0.00008620128,0.001900594,0.00007557777,0.9951347,0.0001251868],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004296138,0.9435798,0.0553328,0.0001165974,0.0003672492,0.0001265637,0.0000217525,9.373613e-7,0.00002467452],"genre_scores_gemma":[0.02102788,0.9773743,0.001041287,0.00001331191,0.0005175194,0.000005955666,0.000006226033,0.000009145648,0.000004340222],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9951015,"threshold_uncertainty_score":0.2903054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06121968719885937,"score_gpt":0.374863738915066,"score_spread":0.3136440517162067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}