{"id":"W3002186531","doi":"10.1021/acssynbio.9b00399","title":"Synthetic Derivatives of (+)-<i>epi</i>-α-Bisabolol Are Formed by Mammalian Cytochromes P450 Expressed in a Yeast Reconstituted Pathway","year":2020,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation","keywords":"Cytochrome P450; Biochemistry; Enzyme; Yeast; Chemistry; Reductase; Biosynthesis; Natural product; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002007751,0.0003700815,0.0005726143,0.0000623542,0.00006368882,0.00001342285,0.0005605167,0.0005301869,0.00008445136],"category_scores_gemma":[0.0008229423,0.0003320009,0.0001436215,0.0002160334,0.0006038681,0.00000916915,0.0001987143,0.0001868003,0.00001819222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001679967,"about_ca_system_score_gemma":0.0001150186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000232641,"about_ca_topic_score_gemma":0.00002325065,"domain_scores_codex":[0.9978258,0.0002232894,0.0005476654,0.0007874811,0.000107268,0.0005084845],"domain_scores_gemma":[0.9988554,0.0001038139,0.0003173926,0.0004773959,0.00007081694,0.0001751453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003115361,0.0001522691,0.002034939,0.0001012959,0.00007496603,0.00001135063,0.00009733084,0.000003416217,0.9941217,0.0000914815,0.0008363591,0.002163371],"study_design_scores_gemma":[0.0006173843,0.0002682555,0.0005101573,0.0001055624,0.0000246386,0.00003658116,0.0003285071,0.00002025406,0.9756226,0.000104551,0.02197223,0.0003893015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939663,0.000844818,0.0004449442,0.00174371,0.00006970618,0.0003252615,0.001403171,0.00003286773,0.001169174],"genre_scores_gemma":[0.9982435,0.0002749109,0.000346573,0.0005093502,0.0000893361,0.00006351306,0.0003448725,0.00002887003,0.00009909049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02113587,"threshold_uncertainty_score":0.9999132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485211911811981,"score_gpt":0.2224216783131976,"score_spread":0.2075695591950778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}