{"id":"W3002186531","doi":"10.1021/acssynbio.9b00399","title":"Synthetic Derivatives of (+)-<i>epi</i>-α-Bisabolol Are Formed by Mammalian Cytochromes P450 Expressed in a Yeast Reconstituted Pathway","year":2020,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation","keywords":"Cytochrome P450; Biochemistry; Enzyme; Yeast; Chemistry; Reductase; Biosynthesis; Natural product; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394453,0.0005005169,0.0002184246,0.0001351615,0.00007228128,0.0002043483,0.0001918754,0.0001621382,0.0008092198],"category_scores_gemma":[0.0001388098,0.0001379726,0.000248634,0.0002092399,0.0001345364,0.0002211212,0.000153499,0.0004655815,0.0003705503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859007,"about_ca_system_score_gemma":0.0001466803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005308702,"about_ca_topic_score_gemma":0.0007583466,"domain_scores_codex":[0.9998815,0.00002344617,0.00001215043,0.00003082224,0.00003286734,0.00001916953],"domain_scores_gemma":[0.9998832,0.00001725299,0.00003713229,0.00002157759,0.00002034978,0.00002043641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006955031,0.00001311859,0.0001433075,0.00002171332,0.000006355689,0.00002659469,0.000008043927,0.00005440124,0.9987978,0.0000541058,0.000009513125,0.0007955636],"study_design_scores_gemma":[0.000002490494,0.00008825836,0.0004507822,0.000001229926,0.000006892324,0.00004123246,0.000008817375,0.0001025376,0.9986211,0.00001083617,0.0006637741,0.000001924641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880419,0.000645593,0.009003415,0.00005289024,0.00002606968,0.0000621981,0.0005781202,0.000110774,0.001479049],"genre_scores_gemma":[0.986672,0.0006912728,0.008953506,0.00002530529,0.000005296609,0.00002308886,0.00154164,0.00005809424,0.002029716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008092198,"threshold_uncertainty_score":0.002707124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485211911811981,"score_gpt":0.2224216783131976,"score_spread":0.2075695591950778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}