{"id":"W3002194251","doi":"10.9734/jpri/2019/v31i630381","title":"The Innovative Potential of Antibody Engineering Enhanced the Clinical Value of Immunotherapy","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Research International","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Antibody; Expansive; Antigen; Monoclonal antibody; Immune system; Immunology; Computational biology; Immunotherapy; Polyclonal antibodies; Computer science; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021977,0.0005321918,0.0005965863,0.0009586803,0.0003549262,0.001605504,0.0005616559,0.001147712,0.004529651],"category_scores_gemma":[0.001002414,0.0002612531,0.0007222546,0.0004978492,0.001006818,0.001613897,0.0008960778,0.002344517,0.001547985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008418643,"about_ca_system_score_gemma":0.0008226007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003299517,"about_ca_topic_score_gemma":0.0003113277,"domain_scores_codex":[0.9991672,0.0002575376,0.00004045108,0.0001558756,0.0002878398,0.00009106156],"domain_scores_gemma":[0.9995475,0.0001706961,0.0000633113,0.00004647768,0.0001287512,0.00004320833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003607941,0.0002874283,0.002374549,0.004243645,0.0001405446,0.0006897789,0.0003834935,0.004289268,0.2776266,0.1786118,0.01640293,0.5145891],"study_design_scores_gemma":[0.00008665695,0.001303112,0.001999393,0.0006409509,0.0001650246,0.002930682,0.000165289,0.007538582,0.1808162,0.0515837,0.752677,0.00009351398],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.06705771,0.5965273,0.2030118,0.01401779,0.003587115,0.0002459837,0.0004796445,0.0008631963,0.1142094],"genre_scores_gemma":[0.5781991,0.2973393,0.0767559,0.005899151,0.002996978,0.0003268427,0.0005026429,0.0001948799,0.03778518],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004529651,"threshold_uncertainty_score":0.01515323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1669570379275066,"score_gpt":0.5528314571768657,"score_spread":0.3858744192493591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}