{"id":"W3002204673","doi":"10.1016/j.nicl.2020.102199","title":"Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Directorate for Biological Sciences; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Alan Turing Institute; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Biotechnology and Biological Sciences Research Council; Wellcome Trust; University of Southern California; Janssen Alzheimer Immunotherapy Research And Development; European Commission; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Neurocognitive; Psychology; Cognition; Cognitive decline; Neuropsychology; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Disease; Medicine; Psychiatry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001536154,0.0005263918,0.0004531913,0.0005296786,0.0001396631,0.0005188934,0.0006377514,0.0006121277,0.0004887143],"category_scores_gemma":[0.005013395,0.0001905334,0.0004967204,0.000409344,0.0003059685,0.0004521481,0.0006071627,0.0009246798,0.0001547653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006151388,"about_ca_system_score_gemma":0.0006294718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01009319,"about_ca_topic_score_gemma":0.007674872,"domain_scores_codex":[0.9996587,0.0001326213,0.00002505133,0.00009963949,0.00004211415,0.00004195149],"domain_scores_gemma":[0.9984558,0.0009919911,0.0002168914,0.00008946045,0.0001713615,0.00007449515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002528888,0.0001058516,0.06108182,0.00006254467,0.0001078392,0.0001579331,0.0001715602,0.8748153,0.001446033,0.002215296,0.0009358481,0.05864702],"study_design_scores_gemma":[0.000004540219,0.00003696762,0.003543764,0.000004867202,0.000006075809,0.00001637536,0.00001061747,0.9940316,0.0001561515,0.002070697,0.0001132,0.000005126142],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7517611,0.0007566155,0.2444027,0.0007854984,0.000046334,0.00009778609,0.001187782,0.0003522826,0.0006099542],"genre_scores_gemma":[0.9811673,0.0001635772,0.01704326,0.00004960581,0.00001099154,0.00005283835,0.0009169552,0.00001160881,0.0005838811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01009319,"threshold_uncertainty_score":0.02006888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1344662828520946,"score_gpt":0.4124104682438249,"score_spread":0.2779441853917303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}