{"id":"W3002204673","doi":"10.1016/j.nicl.2020.102199","title":"Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; Directorate for Biological Sciences; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Alan Turing Institute; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Biotechnology and Biological Sciences Research Council; Wellcome Trust; University of Southern California; Janssen Alzheimer Immunotherapy Research And Development; European Commission; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Neurocognitive; Psychology; Cognition; Cognitive decline; Neuropsychology; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Disease; Medicine; Psychiatry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003958015,0.0001773959,0.0005070897,0.00006525769,0.00004777365,0.00002477062,0.0001409101,0.00005645913,0.0002515319],"category_scores_gemma":[0.005609007,0.000156373,0.000257792,0.0003431959,0.0002314303,0.0000826492,0.0002054784,0.0004116371,0.0001720917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004517076,"about_ca_system_score_gemma":0.0002528737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005827587,"about_ca_topic_score_gemma":5.864239e-7,"domain_scores_codex":[0.9976155,0.0002159556,0.0006850202,0.000574714,0.0005771503,0.0003316228],"domain_scores_gemma":[0.9968606,0.001296774,0.00009126993,0.000194423,0.0004597993,0.001097138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006862557,0.001636921,0.9735579,0.0001480934,0.0002249762,0.002139153,0.0002309356,0.00007613943,0.0002898582,0.00004387196,0.0005988719,0.01419066],"study_design_scores_gemma":[0.003370345,0.004556341,0.9694946,0.0002315202,0.001031432,0.00001441789,0.0001181256,0.0190584,0.001213534,0.00009690157,0.000615434,0.0001988779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756479,0.0001906601,0.01525045,0.006585809,0.000113409,0.001212373,0.00006577678,0.00007587197,0.0008577932],"genre_scores_gemma":[0.992501,0.00005281911,0.0008759085,0.005977684,0.0004101602,0.0000446993,0.00004731406,0.0000359715,0.00005446395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01898227,"threshold_uncertainty_score":0.671491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1344662828520946,"score_gpt":0.4124104682438249,"score_spread":0.2779441853917303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}