{"id":"W3002221608","doi":"10.1016/j.bbi.2020.01.011","title":"The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine","year":2020,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"Janssen Research and Development","keywords":"Escitalopram; Metabolite; Kynurenine; Pharmacology; Serotonin; Kynurenine pathway; Citalopram; Plasma concentration; Medicine; Chemistry; Internal medicine; Tryptophan; Antidepressant; Hippocampus; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006908911,0.0002142191,0.0002414542,0.00004713739,0.00108429,0.0002446219,0.0001605448,0.00006887358,0.000005622574],"category_scores_gemma":[0.002284384,0.0001242148,0.0000384028,0.0002536614,0.0006712889,0.0001455659,0.0001672801,0.000240563,0.000002943445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001321367,"about_ca_system_score_gemma":0.00003245949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005735904,"about_ca_topic_score_gemma":0.00002991637,"domain_scores_codex":[0.9981071,0.0009396552,0.0002241392,0.0003341699,0.0001493335,0.0002455998],"domain_scores_gemma":[0.995164,0.004274859,0.00006377153,0.0002651786,0.00001772942,0.0002144561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006606167,0.0003123912,0.3996668,0.00004856815,0.00005288579,0.00003712192,0.0414171,0.000001817841,0.3491685,0.01066563,0.0002259245,0.1917971],"study_design_scores_gemma":[0.003007292,0.0004520357,0.9732099,0.000009202866,0.00004239905,0.00002153259,0.0007114862,0.00002280052,0.01615838,0.0003263364,0.005871831,0.00016677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837061,0.0007183114,0.00001494203,0.0143895,0.00003033845,0.000926362,0.0001335366,0.00004235279,0.00003861644],"genre_scores_gemma":[0.9985514,0.0001099295,0.00008467677,0.0007525847,0.00002434052,0.0001161589,0.000004437013,0.00001728314,0.0003391445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5735432,"threshold_uncertainty_score":0.8339595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09295589247186287,"score_gpt":0.3061309749673264,"score_spread":0.2131750824954636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}