{"id":"W3002232323","doi":"10.1021/jasms.9b00130","title":"Comparing the Conformational Stability of Pyruvate Kinase in the Gas Phase and in Solution","year":2020,"lang":"en","type":"article","venue":"Journal of the American Society for Mass Spectrometry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada); York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Pyruvate kinase; Gas phase; PKM2; Stability (learning theory); Chromatography; Computational chemistry; Biochemistry; Physical chemistry; Enzyme; Glycolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422409,0.0002235493,0.0001684584,0.00021301,0.0001668027,0.0002519301,0.0002050157,0.0002041628,0.000843025],"category_scores_gemma":[0.0004035687,0.00007303101,0.000127091,0.0002538002,0.0002715344,0.0002474041,0.0001761633,0.0004365888,0.0001544448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289109,"about_ca_system_score_gemma":0.0001364879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005562442,"about_ca_topic_score_gemma":0.000390118,"domain_scores_codex":[0.9998653,0.00002224118,0.000006627093,0.00004673393,0.00003664003,0.0000224903],"domain_scores_gemma":[0.9998776,0.00003843374,0.00003534841,0.00001370568,0.00001953024,0.00001537992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008380334,0.00001705822,0.001397844,0.00002784775,0.00001407787,0.00001554971,0.00004806115,0.0002723389,0.9962245,0.0001334001,0.00003154901,0.001733781],"study_design_scores_gemma":[0.000004827921,0.0001586608,0.01445291,0.000003913258,0.000009875002,0.0001206444,0.00006766351,0.003971814,0.9804311,0.0001430906,0.0006244614,0.00001101887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995203,0.0005655651,0.003440897,0.00004034896,0.00000959903,0.000006265335,0.0002199363,0.00003955519,0.0004748648],"genre_scores_gemma":[0.9976919,0.0002645147,0.001345575,0.00001615612,0.000002865396,0.000007953696,0.0003377881,0.00001149026,0.0003218378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000843025,"threshold_uncertainty_score":0.002820194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668161180010953,"score_gpt":0.2698839120058719,"score_spread":0.2532023002057623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}