{"id":"W3002247662","doi":"10.1016/j.omto.2020.01.002","title":"MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Occupational Cancer Research Centre; St. Paul's Hospital; University of British Columbia","funders":"Providence Health Care Research Institute; Canadian Institutes of Health Research; BC Cancer Foundation; British Columbia Lung Association; Vancouver Coastal Health Research Institute; University of British Columbia; Michael Smith Health Research BC; Terry Fox Research Institute","keywords":"Oncolytic virus; KRAS; Adenocarcinoma; Cancer research; Coxsackievirus; Toxicity; Lung cancer; Cancer; Mutant; Cytotoxicity; Biology; Virus; In vitro; Medicine; Virology; Pathology; Gene; Internal medicine; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003622129,0.0004050312,0.0004693675,0.00009670397,0.0001368927,0.00005698489,0.0007285595,0.0003032229,0.00009527027],"category_scores_gemma":[0.0001783641,0.0004211195,0.0002860175,0.0004760755,0.0001488745,0.00001428756,0.0001706793,0.000279595,0.0000190088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001275221,"about_ca_system_score_gemma":0.0007619353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003630056,"about_ca_topic_score_gemma":0.0000324762,"domain_scores_codex":[0.9972427,0.0002873871,0.0005977315,0.0007269628,0.0005835963,0.0005616213],"domain_scores_gemma":[0.9981074,0.00003140695,0.0003273945,0.0007125533,0.0004654129,0.0003558178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002086988,0.0002244626,0.0004069656,0.00008464311,0.0003196103,0.00002634474,0.0002391458,0.003049834,0.9626313,0.00002712929,0.0004226043,0.03048095],"study_design_scores_gemma":[0.001946853,0.002409373,0.0001213446,0.00006936393,0.00005064434,0.00000428244,0.00007314892,0.007910766,0.9820131,0.00001643598,0.004939187,0.0004454812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750481,0.0189933,0.002597134,0.001230556,0.00007962935,0.0009712047,0.0001005713,0.00004627844,0.0009332097],"genre_scores_gemma":[0.9867433,0.00811949,0.0004970336,0.003818362,0.0002603476,0.0001121628,0.0001648572,0.0001241552,0.0001602554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03003547,"threshold_uncertainty_score":0.999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05024284817363103,"score_gpt":0.3391816393030059,"score_spread":0.2889387911293749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}