{"id":"W3002247662","doi":"10.1016/j.omto.2020.01.002","title":"MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Occupational Cancer Research Centre; St. Paul's Hospital; University of British Columbia","funders":"Providence Health Care Research Institute; Canadian Institutes of Health Research; BC Cancer Foundation; British Columbia Lung Association; Vancouver Coastal Health Research Institute; University of British Columbia; Michael Smith Health Research BC; Terry Fox Research Institute","keywords":"Oncolytic virus; KRAS; Adenocarcinoma; Cancer research; Coxsackievirus; Toxicity; Lung cancer; Cancer; Mutant; Cytotoxicity; Biology; Virus; In vitro; Medicine; Virology; Pathology; Gene; Internal medicine; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006196048,0.001106967,0.0011995,0.0002932965,0.0004275996,0.001113261,0.0009809728,0.001601955,0.006951761],"category_scores_gemma":[0.001066866,0.0004787041,0.0006490811,0.000373997,0.0006188774,0.0006514784,0.0003650664,0.001935987,0.002175356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007184774,"about_ca_system_score_gemma":0.0007712616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328571,"about_ca_topic_score_gemma":0.002777971,"domain_scores_codex":[0.9995514,0.00004875188,0.00004930162,0.00007132973,0.0001968117,0.00008231341],"domain_scores_gemma":[0.9997616,0.00007459336,0.00006598807,0.00002588631,0.00004030344,0.0000316091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009013988,0.0001434993,0.0005736994,0.001897554,0.0001977103,0.001575605,0.0001285095,0.001187874,0.7636338,0.009653321,0.1229029,0.09720418],"study_design_scores_gemma":[0.0001755079,0.0007457965,0.003588704,0.0001165751,0.0002766849,0.004957174,0.0001171964,0.003000453,0.5654273,0.001168298,0.4203074,0.0001189672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"editorial","genre_gemma":"empirical","genre_scores_codex":[0.2918156,0.2008777,0.05797723,0.05143429,0.3485189,0.0002728096,0.005183695,0.006148697,0.03777114],"genre_scores_gemma":[0.769459,0.1021612,0.0270077,0.01456599,0.01364923,0.0002323507,0.003198363,0.001980976,0.06774522],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006951761,"threshold_uncertainty_score":0.02325594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05024284817363103,"score_gpt":0.3391816393030059,"score_spread":0.2889387911293749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}