{"id":"W3002291382","doi":"10.1016/j.tips.2019.12.007","title":"Tetrahydroprotoberberines: A Novel Source of Pharmacotherapies for Substance Use Disorders?","year":2020,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Dopamine; Neuroscience; Receptor; Dopamine receptor; Dopamine receptor D2; Pharmacology; Drug; Mechanism (biology); Computational biology; Medicine; Psychology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840948,0.0006372742,0.0015477,0.001286899,0.0001732831,0.0009660581,0.0007383585,0.0009271287,0.007977271],"category_scores_gemma":[0.0005014261,0.0002217466,0.0004864151,0.0012469,0.0003830332,0.001138989,0.0004378915,0.001562922,0.003191183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388303,"about_ca_system_score_gemma":0.000711371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029347,"about_ca_topic_score_gemma":0.003470623,"domain_scores_codex":[0.9998932,0.00001869735,0.00001450842,0.00002179709,0.00003688535,0.00001493209],"domain_scores_gemma":[0.9998654,0.00005132562,0.00003375036,0.000004911793,0.00002908608,0.00001546448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003747424,0.0001039962,0.0001460877,0.01638592,0.0002205231,0.0002322448,0.00003898004,0.0001832752,0.003740997,0.003354112,0.02002254,0.9551966],"study_design_scores_gemma":[0.0002574973,0.0003782086,0.001349364,0.003918854,0.0004545187,0.001350513,0.00007220661,0.0001470079,0.001135382,0.00277572,0.9881286,0.00003221848],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003661551,0.9973895,0.0001658774,0.0004614827,0.0002319075,0.000006980461,0.00006241229,0.00001383019,0.001301814],"genre_scores_gemma":[0.002006116,0.9959524,0.0002405526,0.0004524146,0.0002010463,0.000007737064,0.00006509054,0.000002512207,0.001072127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007977271,"threshold_uncertainty_score":0.02668667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1868136469388265,"score_gpt":0.4654191119660724,"score_spread":0.2786054650272458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}