{"id":"W3002304403","doi":"10.1016/j.bbamem.2020.183202","title":"Intrinsically disordered regions regulate the activities of ATP binding cassette transporters","year":2020,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"ATP-binding cassette transporter; Membrane protein; Cyclic nucleotide-binding domain; ATP hydrolysis; Biochemistry; Cell biology; Nucleotide; Plasma protein binding; Chemistry; Protein domain; Cytosol; Protein family; Biology; Biophysics; Membrane; Transporter; ATPase; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311572,0.0006262264,0.0009498586,0.0008223461,0.0001381346,0.0008750223,0.0005449165,0.0006572909,0.001145292],"category_scores_gemma":[0.0003446839,0.0001706129,0.0002546697,0.0009827871,0.0004364889,0.0007906922,0.00051055,0.001016453,0.0007110165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004730066,"about_ca_system_score_gemma":0.0005075959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004459858,"about_ca_topic_score_gemma":0.0007773335,"domain_scores_codex":[0.9998914,0.00001684487,0.00001452423,0.00002064748,0.00003746628,0.00001915307],"domain_scores_gemma":[0.9998661,0.00005788861,0.0000345271,0.00000384099,0.00002676269,0.00001078801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002284179,0.00004963807,0.0003713441,0.01098898,0.0001162145,0.0003983006,0.00007914883,0.0007655449,0.0157307,0.009451001,0.01382091,0.9479997],"study_design_scores_gemma":[0.0000384654,0.0001184481,0.001763248,0.001643918,0.0002039019,0.001648279,0.00005830073,0.000303537,0.005172945,0.004262774,0.984753,0.00003326298],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003719416,0.9987044,0.0001595345,0.0001553808,0.00007860599,0.000002001618,0.00001601938,0.000006019873,0.0005060487],"genre_scores_gemma":[0.002632696,0.9964622,0.0001759414,0.0001312345,0.0001227716,0.000003911226,0.00004438292,0.000001215095,0.0004256336],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001145292,"threshold_uncertainty_score":0.003831446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325953092576529,"score_gpt":0.3012158305848081,"score_spread":0.2679562996590428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}