{"id":"W3002318915","doi":"10.1016/j.clinthera.2019.11.010","title":"Population Pharmacokinetics and Exposure–Response Modeling of Golimumab in Adults With Moderately to Severely Active Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Merck Sharp and Dohme; Genentech; Sanofi; Kyowa Hakko Kirin; Bristol-Myers Squibb; Akebia Therapeutics; Mitsubishi Tanabe Pharma Corporation; Celltrion; Janssen Scientific Affairs; Janssen Research and Development; UCB; AbbVie; Danone; Therakos; Pfizer; Biogen; Celgene; Novo Nordisk; Janssen Biotech; Teva Pharmaceutical Industries; Gilead Sciences; GlaxoSmithKline; Tillotts Pharma; Allergan; Seres Therapeutics; Amgen; Eli Lilly and Company; Dr. Falk Pharma; Abbott Laboratories","keywords":"Golimumab; Medicine; Pharmacokinetics; Population; Ulcerative colitis; Internal medicine; Adverse effect; Pharmacology; Gastroenterology; Etanercept; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002258679,0.0004243471,0.0007768309,0.0002167481,0.0001425698,0.0007977252,0.0003971489,0.0005989578,0.001145912],"category_scores_gemma":[0.004442015,0.0003514066,0.0008830581,0.0001953906,0.0002041691,0.0003251827,0.000360123,0.0009237155,0.0001937094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004196723,"about_ca_system_score_gemma":0.0005321646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003453722,"about_ca_topic_score_gemma":0.0016991,"domain_scores_codex":[0.9994344,0.0003622282,0.00001859635,0.00009017192,0.00003961101,0.00005502288],"domain_scores_gemma":[0.9985257,0.001075333,0.000180855,0.00009877689,0.00006212178,0.00005725132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01464937,0.001268942,0.240461,0.0002637184,0.00382112,0.001680487,0.0006797239,0.6561967,0.008313713,0.004426993,0.003146761,0.06509146],"study_design_scores_gemma":[0.0004636715,0.002868126,0.08183023,0.00003244383,0.001103111,0.0008869378,0.0001984781,0.9048735,0.001482148,0.004076711,0.002135699,0.00004894589],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842141,0.0006481338,0.01327012,0.0003323626,0.00001273832,0.00004218246,0.0004278397,0.00009601236,0.0009564561],"genre_scores_gemma":[0.9973816,0.0001901826,0.001441734,0.00007295182,0.000008637155,0.0000317074,0.0002503044,0.000009132951,0.0006136002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003453722,"threshold_uncertainty_score":0.01194513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04707411313754802,"score_gpt":0.3368781198034512,"score_spread":0.2898040066659032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}