{"id":"W3002398905","doi":"10.1161/atvbaha.119.313763","title":"PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension","year":2020,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université Laval","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Canadian Institutes of Health Research; Université Laval","keywords":"Non-homologous end joining; DNA damage; Provirus; Ku80; DNA repair; Cancer research; PIM1; Cell biology; Biology; DNA; Chemistry; Genetics; DNA-binding protein; Gene; Phosphorylation; Transcription factor; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003953941,0.0002681994,0.0005357462,0.0000907392,0.0001972699,0.00003245746,0.00006697256,0.0001979897,0.0001085642],"category_scores_gemma":[0.00007811188,0.0001865973,0.0002183047,0.0002488657,0.0001435967,0.0001150029,0.00009618217,0.0002739363,0.00001103714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009051017,"about_ca_system_score_gemma":0.00008308751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005937804,"about_ca_topic_score_gemma":0.0001693327,"domain_scores_codex":[0.9983157,0.0002323698,0.0004224208,0.0005763169,0.0001358036,0.0003173768],"domain_scores_gemma":[0.9992735,0.00008862872,0.0001275949,0.0002979949,0.00006749741,0.0001447612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005469317,0.0001174252,0.01383065,0.00003923323,0.00008274795,0.000006050268,0.0008919423,0.000005749971,0.9814695,0.000254249,0.00003262266,0.003215145],"study_design_scores_gemma":[0.003024949,0.002266855,0.881749,0.000518208,0.0001832472,0.00002817548,0.0009750552,0.006020505,0.1032788,0.0002320754,0.001267778,0.0004553543],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964334,0.0002574649,0.0006086337,0.001869154,0.00009591831,0.0005559039,0.00001731943,0.0001216172,0.0000405722],"genre_scores_gemma":[0.992371,0.001137042,0.0006243868,0.005385866,0.0001842379,0.00008580561,0.0001756742,0.00003468513,0.000001314949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8781906,"threshold_uncertainty_score":0.7609218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04255803229964122,"score_gpt":0.2557724089463158,"score_spread":0.2132143766466745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}