{"id":"W3002496690","doi":"10.1038/s41467-019-13962-0","title":"FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; St Joseph's Health Care; St Joseph's Health Centre; McGill University; Jewish General Hospital","funders":"National Human Genome Research Institute; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health","keywords":"Neuroinflammation; Atrophy; Phenotype; Amyloid precursor protein; Amyloid (mycology); Neuroscience; Alzheimer's disease; Biology; Pathology; Disease; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399751,0.0007922798,0.0003482215,0.0006289614,0.0003683348,0.0004129298,0.0002389989,0.0007761336,0.002533766],"category_scores_gemma":[0.0003089584,0.0001462889,0.0003814939,0.0005190438,0.0002540874,0.0002532291,0.000244688,0.0003661594,0.001734187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110773,"about_ca_system_score_gemma":0.0001667125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008928542,"about_ca_topic_score_gemma":0.0007212259,"domain_scores_codex":[0.9998887,0.00001768105,0.00001294539,0.00004108726,0.00002583184,0.00001367214],"domain_scores_gemma":[0.9998721,0.00002187659,0.00004948573,0.00001025181,0.00001477655,0.00003154427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003948366,0.00004909589,0.004114802,0.0001096483,0.00005001602,0.004665195,0.00006552554,0.0001567764,0.9755155,0.0003689753,0.001020969,0.01348871],"study_design_scores_gemma":[0.0001740846,0.001008719,0.09461363,0.00009355299,0.0002289339,0.0673519,0.0001729866,0.002969634,0.7054738,0.0008986995,0.1269249,0.00008922532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961556,0.0128441,0.01142855,0.0007655112,0.000490138,0.00008947612,0.007229953,0.0007097662,0.00488636],"genre_scores_gemma":[0.9711134,0.00399088,0.008810362,0.0003399327,0.0001235092,0.00006701682,0.007320658,0.00007909835,0.008155087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002533766,"threshold_uncertainty_score":0.008476257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08271782812816093,"score_gpt":0.3919622497895588,"score_spread":0.3092444216613979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}